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FGFR1 Antibodies
AND FGFR1 ELISA kits, FGFR1 Proteins
Many biological assays use antibodies to detect FGFR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FGFR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FGFR1 antibodies...
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FGFR1 Infographic by Boster Bio
All FGFR1 Products
Product
Figures
Specificity
Applications
Price
Anti-FGFR1 Antibody Picoband®
5 Citations 6 Q&As
Human, Mouse, Rat
IHC, WB
$370
Cat # PA1477
100 μg/vial
Cat # PA1477
100 μg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1211
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1211
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2069
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2069
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2070
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2070
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2409
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2409
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, WB
$380
Cat # A00098Y463
100ul
Cat # A00098Y463
100ul
FGFR1 Overview
Facts about Fibroblast growth factor receptor 1.
Fibroblast growth factor receptor 1 (FGFR1)
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, migration and differentiation. Required for normal mesoderm patterning and proper axial organization during embryonic development, normal skeletogenesis and regular development of the gonadotropin-releasing hormone (GnRH) neuronal system.
Ligand binding contributes to the activation of several signaling cascades. Activation of PLCG1 contributes to the creation of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.
Gene Information
| Human | |
|---|---|
| Gene Name: | FGFR1 |
| Uniprot: | P11362 |
| Entrez: | 2260 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; CD331 antigen; CD331; CEK; EC 2.7.10; EC 2.7.10.1; FGF R1; FGFBR; FGFR1; FGFR-1; fibroblast growth factor receptor 1; FLGH3; FLJ99988; Flt-2; FLT2H4; Fms-like tyrosine kinase 2; fms-related tyrosine kinase 2; H2; H5; HBGFR; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; KAL 2; KAL2; N-SAM; OGD; Proto-oncogene c-Fgr; soluble FGFR1 variant 1; soluble FGFR1 variant 2
Molecular Weight
Mass (kDA):
91.868 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p11.23 |
| Sequence: | 8; NC_000008.11 (38411138..38468834, complement) |
Tissue Specificity
Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Tumor Angiogenesis
- Carcinoma
- Myeloproliferative Disease
- Leukemia
- Kallmann Syndrome
- Hypogonadism
- Hypogonadotropic Hypogonadism
- Craniosynostosis
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Mammary Neoplasms
Interacting Proteins
- ANOS1
- CDH1
- CRK
- CTNNB1
- FGF1
- FGF2
- FGF23
- Grb14
- HTR1A
- Kl
Pathways
- Cell Proliferation
- Angiogenesis
- Localization
- Pathogenesis
- Cell Growth
- Regeneration
- Secretion
- Cell Adhesion
- Cell Cycle
- Cell Differentiation
- Cell Migration
- Wound Healing
- Neurogenesis
PTMs
- Phosphorylation
- Cleavage
- Glycosylation
- Methylation
- Biotinylation
- Reduction
Research Areas
- Angiogenesis
- Core ESC-Like Genes
- Oncogenes
- Protein Kinase
- Signal Transduction
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FGFR1
bosterbio.com/bosterbio-gene-info-cards/FGFR1
References
PMID: 2162671 by Itoh N., et al. The complete amino acid sequence of the shorter form of human basic fibroblast growth factor receptor deduced from its cDNA.
PMID: 1697263 by Dionne C.A., et al. Cloning and expression of two distinct high-affinity receptors cross- reacting with acidic and basic fibroblast growth factors.
6 Publications of Boster FGFR1 Antibodies & ELISA Kits
- PubMed ID: 10.1097/WNR.0000000000001591, Expression of fibroblast growth factor 9 and its receptors in the dentate gyrus ...
- PubMed ID: 31028291, Zhang JJ,Zhou XH,Zhou Y,Wang YG,Qian BZ,He AN,Shen Z,Hu HY,Yao Y.Bufalin suppres...
- PubMed ID: 32801884, Chen Y,Zhang S,Bai C,Guan Z,Chen W.Circ_0000885 Enhances Osteosarcoma Progressio...
- PubMed ID: 30066343 , Regulation of 25-hydroxyvitamin D-1-hydroxylase and 24-hydroxylase in keratinocy...
- PubMed ID: 16999598, Zhang H, Zhang S, Zhuang H, Lu F. Cancer Biother Radiopharm. 2006 Aug;21(4):321-...
- PubMed ID: 21615804, Lin J, Jia Y, Zeng W, Mi Y, Zhang C. Reprod Domest Anim. 2012 Feb;47(1):135-42. ...
*More publications can be found for each product on its corresponding product page