Fibrinogen beta chain (FGB)

Cleaved by the protease thrombin to yield monomers that, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a significant function in hemostasis among the principal elements of blood clots.

In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.