Fibrinogen beta chain Antibodies

Fibrinogen beta chain (FGB)

Cleaved by the protease thrombin to yield monomers that, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a significant function in hemostasis among the principal elements of blood clots.

In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.

Gene Information

Human
Gene Name:	FGB
Uniprot:	P02675
Entrez:	2244

Family

Belongs to:
No superfamily

Alternative Names

Beta-Fibrinogen; FGB Peptide; FIBB; Fibrinogen beta chain; Fibrinogen Type II; fibrinogen, B beta polypeptide; Fibrinopeptide B; FPB; MGC104327; MGC120405

Molecular Weight

Mass (kDA):
55.928 kDA

Genomic Context

Human
Location:	4q31.3
Sequence:	4; NC_000004.12 (154562980..154572807)

Tissue Specificity

Detected in blood plasma (at protein level).

Subcellular Localizations

Secreted.

Diseases

• Afibrinogenemia
• Hereditary Factor I Deficiency Disease
• Infarction
• Cardiovascular Diseases
• Myocardial Infarction
• Hemorrhage
• Inflammation
• Cerebrovascular Accident
• Hypofibrinogenemia
• Blood Coagulation Disorders
• Dysfibrinogenemia
• Thrombosis
• 5,10-methylenetetrahydrofolate Reductase Deficiency

• Ischemic Stroke
• Dysequilibrium Syndrome
• Diabetes Mellitus
• Hypertensive Disease
• Bleeding Tendency
• Thrombophilia
• Atherosclerosis

Pathways

• Coagulation
• Secretion
• Hemostasis
• Pathogenesis
• Mrna Splicing
• Inflammatory Response
• Translation
• Fibrinolysis
• Mrna Processing
• Meiosis
• Fertilization
• Complement Activation
• Chromosome Segregation

• Platelet Aggregation
• Rna Surveillance
• Cell Cycle
• Regulation Of Mitosis
• Cognition
• Meiosis I
• Wound Healing

PTMs

• Nitration

Research Areas

• Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FGB

Best Uses Of The FGB Marker

When choosing the flow procedure for your biological research there are many factors to consider. FGB antibody antibodies are utilized to react with the Fibrinogen beta chain. Boster Bio has many flow methods to pick from. To get the most out of your experiment make sure you follow these tips and guidelines. Boster Bio support can help you with any questions about your experiment. We'll be happy to help!

In biological tests, fibrinogen beta chain antibodies can be used

Aa chains, the longest subunits of fibrinogen extend into the highly flexible globular aC region. Fibrinogen Aalpha Polymorphism Thr312Ala and studies by Standeven KF and Grant PJ have all shed light on the pleiotropic roles played by this subunit in hemostasis as well as thrombosis.

The fibrinogen alpha chains can be detected by monoclonal or polyclonal antibodies that are specific to the alpha chain. These antibodies recognize fibrinogen from diverse animal specimens. Companies such as Boster Bio develop monoclonal antibodies made from mouse and rabbit samples. Fibrin is an essential component in hemostasis. It plays an important role in the beginning phases of wound healing stabilizing the lesion as well as controlling cell migration during the re-epithelialization process. Fibrin was once believed to be necessary for platelet aggregation in vivo and the formation of thrombuses, but subsequent studies have proven that it isn't essential.

While both chains of fibrinogen can be found in the glia limitans and astrocytes of the brain Both subunits play different functions in the body. Fibrinogen beta chain G which is the most well-known subunit of the peripheral nerve system, is more widespread and interacts with many molecules. Fibrinogen chain aa is expressed by neurons, astrocytes, and fibrinogen ba or g.

Fibrinogen chain polymorphisms alter the structure of fibrin and its clot rigidity. Numerous studies have demonstrated that MI risk is lower in people who carry of fibrinogen -455AA. Nevertheless, there are still questions to answer. Fibrinogen is an essential molecule in a number of physiological processes, and its role in biological assays requires further investigation.

Fibrinogen is an enormous plasma glycoprotein produced by the hepatocytes. It is comprised of six polypeptide chain and plays a crucial role in hemostasis aswell as thrombosis. It is a molecule made up of three genes. The genes are clustered at 4q32 within a compact locus. The transcription of Fibrinogen genes is controlled by the binding sites of transcription factors.

They react to Fibrinogen beta-chain

Boster Bio FGB markers react with Fibrosis-related protein also referred to as fibrinopeptides. These proteins are found in the blood of humans and most vertebrates. This means that they share a blood coagulation system. The blood contains fibrinopeptides , which are degraded from fibrinogen with thrombin the proteinase. It is involved in blood coagulation and wound healing as and cellular interactions. Mutations in the FGB protein may lead to various disorders.

The three most commonly used Boster Bio FGB markers are CTfg, CTfg and CTfn3. Both proteins are present in the blood of people with chronic and acute inflammation. They can be used to determine inflammation. The arrows point to possible glycosaminoglycan-related addition sites. The cross represents the RGD site and the arrow is the Ca2+-binding site on fibrinogen beta chains.

Steven Boster's story

As the creator of the first ELISA kit Steven Boster's background is quite impressive. It includes all of his prior and current residence addresses including cellphone numbers, email addresses, and even family members he knew. By using the appropriate tools, you can quickly and easily find Steve Boster's background. You can also sort the results by age and state to find the most relevant information. To learn more about Steven Boster, read on.

Steve Boster passed away on June 6, 2022. He was born in Joliet (IL). He was a former retail sales manager and a member of Concordia Hall in Staunton. He is survived by two daughters Natosha Peck, and Crystal Boster, 6 Grandchildren and 4 brothers Jack Boster and Sandra Blanton and nieces and nephews. Steve Boster is not being burial.