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- Table of Contents
Facts about Tyrosine-protein kinase Fes/Fps.
Acts down- flow of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation.
Human | |
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Gene Name: | FES |
Uniprot: | P07332 |
Entrez: | 2242 |
Belongs to: |
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protein kinase superfamily |
EC 2.7.10; EC 2.7.10.2; feline sarcoma oncogene; feline sarcoma virus; Fes; FPS; Proto-oncogene c-Fes; Proto-oncogene c-Fps; proto-oncogene tyrosine-protein kinase Fes/Fps; tyrosine-protein kinase Fes/Fps
Mass (kDA):
93.497 kDA
Human | |
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Location: | 15q26.1 |
Sequence: | 15; NC_000015.10 (90884421..90895776) |
Widely expressed. Detected in adult colon epithelium.
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery.
PMID: 2179816 by Alcalay M., et al. Characterization of human and mouse c-fes cDNA clones and identification of the 5' end of the gene.
PMID: 4065096 by Roebroek A.J.M., et al. The structure of the human c-fes/fps proto-oncogene.