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Flap endonuclease 1 Antibodies
AND FEN1 ELISA kits, Flap endonuclease 1 Proteins
Many biological assays use antibodies to detect Flap endonuclease 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Flap endonuclease 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Flap endonuclease 1 antibodies...
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FEN1 Infographic by Boster Bio
All FEN1 Products
Product
Figures
Specificity
Applications
Price
Anti-FEN1 Antibody Picoband®
1 Q&As
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01484-1
100 μg/vial
Cat # A01484-1
100 μg/vial
Human, Mouse, Rat
IHC, WB
$523
Cat # M01484-1
100 µl
Cat # M01484-1
100 µl
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01484-3
100 μg/vial
Cat # M01484-3
100 μg/vial
Human, Mouse
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01484-4
100 μg/vial
Cat # M01484-4
100 μg/vial
FEN1 Overview
Facts about Flap endonuclease 1.
Flap endonuclease 1 (FEN1)
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that's generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.
Gene Information
| Human | |
|---|---|
| Gene Name: | FEN1 |
| Uniprot: | P39748 |
| Entrez: | 2237 |
Family
| Belongs to: |
|---|
| XPG/RAD2 endonuclease family |
Alternative Names
EC 3.1; FEN1; FEN-1; FEN-1hFEN-1; flap structure-specific endonuclease 1DNase IV; Maturation factor 1; maturation factor-1; MF1flap endonuclease 1; RAD2
Molecular Weight
Mass (kDA):
42.593 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q12.2 |
| Sequence: | 11; NC_000011.10 (61792911..61797238) |
Subcellular Localizations
[Isoform 1]: Nucleus, nucleolus. Nucleus, nucleoplasm. Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.; [Isoform FENMIT]: Mitochondrion.
Diseases
- Malignant Neoplasms
- Genomic Instability
- Neoplasms
- Trinucleotide Repeat Expansion
- Cell Transformation, Neoplastic
- Carcinogenesis
- Malignant Neoplasm Of Lung
- Colorectal Cancer
- Lung Neoplasms
- Huntington Disease
- Mammary Neoplasms
- Dystrophy
- Werner Syndrome
Interacting Proteins
- BLM
- MUS81
- PCNA
- WDR4
- WRN
Pathways
- Dna Replication
- Dna Repair
- Strand Displacement
- Cell Cycle
- Mismatch Repair
- Localization
- S Phase
- Cell Proliferation
- Cell Death
- Translation
- Aging
- Fatty Acid Elongation
- Hypersensitivity
PTMs
- Cleavage
- Phosphorylation
- Methylation
- Acetylation
- Sumoylation
Research Areas
- Base Excision Repair
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FEN1
bosterbio.com/bosterbio-gene-info-cards/FEN1
References
PMID: 8007985 by Murray J.M., et al. Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage.
PMID: 7774922 by Hiraoka L.R., et al. Sequence of human FEN-1, a structure-specific endonuclease, and chromosomal localization of the gene (FEN1) in mouse and human.