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- Table of Contents
Facts about Fc receptor-like A.
Human | |
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Gene Name: | FCRLA |
Uniprot: | Q7L513 |
Entrez: | 84824 |
Belongs to: |
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No superfamily |
Fc receptor homolog expressed in B cells (FREB); Fc receptor homolog expressed in B-cells; Fc receptor related protein X; Fc receptor-like A; Fc receptor-like and mucin-like 1; Fc receptor-related protein X; FCRL1; FCRLA; FCRLb; FCRLc1; FCRLc2; FCRLd; FCRLe; FCRLFc receptor-like protein; FCRLM1; FCRLX; FcRX; FREB; FREBFc receptor-like and mucin-like protein 1; MGC4595
Mass (kDA):
38.927 kDA
Human | |
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Location: | 1q23.3 |
Sequence: | 1; NC_000001.11 (161707022..161714352) |
Expressed specifically in primary and secondary lymphoid tissues like lymph node, spleen and tonsil. Specifically expressed in B-cells with a high level in normal germinal center B-cells, centroblasts and in a subset of diffuse large B-cell lymphomas. Highly expressed in bone marrow B-cells and weakly in earlier B lineage cells. Expressed in pre-germinal and germinal center B-cells in secondary lymphoid tissues. Also expressed in melanoma and melanocytes.
Cytoplasm. Seems not to be secreted.
PMID: 11754007 by Mechetina L.V., et al. FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features.
PMID: 11891275 by Facchetti F., et al. An unusual Fc receptor-related protein expressed in human centroblasts.