Fc receptor-like A Antibodies

Fc receptor-like A (FCRLA)

May be implicated in B-cell differentiation and lymphomagenesis. .

Gene Information

Human
Gene Name:	FCRLA
Uniprot:	Q7L513
Entrez:	84824

Family

Belongs to:
No superfamily

Alternative Names

Fc receptor homolog expressed in B cells (FREB); Fc receptor homolog expressed in B-cells; Fc receptor related protein X; Fc receptor-like A; Fc receptor-like and mucin-like 1; Fc receptor-related protein X; FCRL1; FCRLA; FCRLb; FCRLc1; FCRLc2; FCRLd; FCRLe; FCRLFc receptor-like protein; FCRLM1; FCRLX; FcRX; FREB; FREBFc receptor-like and mucin-like protein 1; MGC4595

Molecular Weight

Mass (kDA):
38.927 kDA

Genomic Context

Human
Location:	1q23.3
Sequence:	1; NC_000001.11 (161707022..161714352)

Tissue Specificity

Expressed specifically in primary and secondary lymphoid tissues like lymph node, spleen and tonsil. Specifically expressed in B-cells with a high level in normal germinal center B-cells, centroblasts and in a subset of diffuse large B-cell lymphomas. Highly expressed in bone marrow B-cells and weakly in earlier B lineage cells. Expressed in pre-germinal and germinal center B-cells in secondary lymphoid tissues. Also expressed in melanoma and melanocytes.

Subcellular Localizations

Cytoplasm. Seems not to be secreted.

Diseases

• Leukemia
• Chronic Lymphocytic Leukemia
• Lymphoid Leukemia
• Malignant Neoplasms
• B-cell Lymphomas
• Malignant Paraganglionic Neoplasm
• Neoplasms
• Lymphoma
• Melanoma
• Acute Lymphocytic Leukemia
• Precursor T-cell Lymphoblastic Leukemia-lymphoma

• Lymphoma, Follicular
• Chromosomal Translocation
• Hairy Cell Leukemia
• Leukemia, B-cell
• Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse
• Lymphoma, Non-hodgkin

Pathways

• Cell Activation
• Cell Development
• B Cell Activation
• Cell Cycle
• Cell Differentiation
• Immune Response
• Glycosylation
• B Cell Differentiation

• Localization
• Secretion

PTMs

• Phosphorylation

• Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FCRLA

Boster Bio: Best Uses of the FCRLA Marker

Although the FCRLA markers have many promising uses, their best uses are still unknown. This article will highlight some of the most recent research conducted at different institutes. Ctr Hlth Aging and Univ Oslo and Synapt Neurchem Lab are examples of these institutions. Boster Bio: Best uses of the FCRLA marker provides more information on the FCRLA genetic gene.

Univ Oslo, Synapt Neurochem Lab

The Neurochem lab at Univ Oslo published results using the fluorescent marker. These results confirm previous research that identified FCRLA as a key component of neurotransmitter NMDA. It was discovered by Professors M. C. Alves, Galeano D. C. Fisone G. and Santos W. S.