FCRL3 Antibodies

AND FCRL3 ELISA kits, FCRL3 Proteins

Many biological assays use antibodies to detect FCRL3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FCRL3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FCRL3 antibodies...

We validate the specificity of these antibodies to FCRL3 by testing them on tissues known to express FCRL3 positively and negatively. Browse below to find the FCRL3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FCRL3 Infographic by Boster Bio

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Anti-Fc receptor-like protein 3 FCRL3 Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A02743
100ul

FCRL3 Overview

Facts about Fc receptor-like protein 3.

FCRL3 3D structure. Source: alphafold

Fc receptor-like protein 3 (FCRL3)

Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366).

Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936).

Gene Information

Human
Gene Name:	FCRL3
Uniprot:	Q96P31
Entrez:	115352

Family

Belongs to:

No superfamily

Alternative Names

CD307c; Fc receptor homolog 3; Fc receptor-like 3; Fc receptor-like protein 3; FcRH3; FCRL3; fcR-like protein 3; hIFGP3; IFGP3; immunoglobulin superfamily receptor translocation associated protein 3; IRTA3; SPAP2

Molecular Weight

Mass (kDA):
80.856 kDA

Genomic Context


Human

Location:	1q23.1
Sequence:	1; NC_000001.11 (157676481..157700985, complement)

Tissue Specificity

Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Low expression on transitional B cells which increases to higher surface expression on mature and memory B-cells with innate-like features (at protein level) (PubMed:23857366). Expressed a low levels in naive and germinal center B-cells but also expressed in NK cells (at protein level). Expressed in a population of thymically derived natrurally ocurring regulatory T-cells that exhibits a memory phenotype, specialized in suppressing immune response to self-antigens (PubMed:20190142). Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus.