FCRL2 Antibodies

Fc receptor-like protein 2 (FCRL2)

May have an regulatory function in normal and neoplastic B cell growth. .

Gene Information

Human
Gene Name:	FCRL2
Uniprot:	Q96LA5
Entrez:	79368

Family

Belongs to:
No superfamily

Alternative Names

CD307b antigen; CD307b; Fc receptor homolog 2; Fc receptor-like 2; FcRH2; FCRH2SPAP1B; FCRL2; FcR-like protein 2; IFGP family protein 4; IFGP4; Immunoglobulin receptor translocation-associated protein 4; immunoglobulin superfamily Fc receptor, gp42; IRTA4; IRTA4SPAP1C; SH2 domain containing phosphatase anchor protein 1; SH2 domain-containing phosphatase anchor protein 1Fc receptor-like protein 2; SPAP1; SPAP1A; SPAP1immune receptor translocation-associated protein 4

Molecular Weight

Mass (kDA):
55.542 kDA

Genomic Context

Human
Location:	1q23.1
Sequence:	1; NC_000001.11 (157745733..157777472, complement)

Tissue Specificity

Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B- cell lines. Preferentially expressed in memory B-cells (at protein level).

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

• Chronic Lymphocytic Leukemia
• Leukemia
• Lymphoid Leukemia
• Malignant Neoplasms
• Neoplasms
• Autoimmunity
• Melanoma
• Thyroid Diseases
• Tumor Angiogenesis
• Lupus Erythematosus, Systemic
• Lymphoma
• Hematological Disease

• Rheumatoid Arthritis
• Pathologic Neovascularization
• Leukemogenesis
• Skin Neoplasms
• Graves Disease
• B-cell Lymphomas
• Acute Lymphocytic Leukemia

Interacting Proteins

• NCK2

Pathways

• Leukocyte Differentiation
• Angiogenesis
• Pathogenesis

PTMs

• Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FCRL2

Boster Bio: Best Uses Of The FCRL2 Marker

The FCRL2 marker can be used to indicate RNA quality in a variety biological samples. It has many useful applications in the pharmaceutical sector. It can be used for scientific purposes, such as to identify special species or applications. Boster scientists are also allowed to submit their results in order to be credited for their work. This marker can be used by scientists all over the world. The FCRL2 has many applications beyond its use in the pharmaceutical and biomedical industries.

FCRL2

The FCRL2 marker is an amino acid that can be used to identify biological entities. It has been validated by a variety of studies that involved malignant B cells (CLL) and chronic lymphocytic Leukemia (CLL). An earlier analysis found that FCRL2 was a good marker to identify CLL patients with incurable disease. This was associated in part with better progression-free survival. In addition, an FCRL2 antibody can segregate CLL samples based on the mutation status of the IGHV gene.

One study found that patients with deletion 13q (MT-CLL) had a higher risk of responding to chemotherapy when FCRL2 was present. The FCRL2 marker also improved prognosis in patients with MT–CLL, and B–CLL with deleted 13q. FCRL2 can be used as an easily accessible diagnostic marker but should be validated.

LYN

The FCRL2 marker can be found on B cell. It is seen to be overexpressed in some types B cell malignancies, which indicates its potential as an immunotherapy target. It is also found in certain human cancers, such as leukemia. Scientists are eager to understand what this protein does and how it can be used in the treatment of such cancers.

The BCR signaling pathway shows that the two FCRL genes are differentially regulated. The smaller, circular nodes are used to indicate joint regulation of downstream genes. The larger, rectangular nodes signify upstream regulatory. The nodes are identified by varying colors that range from white and red. The outlines of the nodes are either blue-green. This research provides insight on the regulation of BCR-signaling by the FCRL2 marking.

LYN3

Although it is too soon to draw any definitive conclusions about the role FCRL2 plays in B-CLL development, it could be a useful indicator of the prognosis for patients at high risk. FCRL2 is not only a easily detectable marker but also a great predictor of treatment response. However, it is not clear if this marker plays any role in the prognosis or treatment response of patients with BCL.

It has not been shown to affect cytotoxic T cell production in vitro but it does play a part in immune response. FCRL6 also regulates the release of cytotoxic cells. However, it is not known whether FCRL6 is an important biomarker in patients with melanoma. However, there are increasing indications that FCRL6 may be a biomarker as well as a therapeutic target for cancer.

LYN4

The FCRL2 marker is highly expressed in B cells. The FCRL members act in an inhibitory tyrosine and BCR signaling regulation way. It is also expressed in tumors other than those belonging to the B lineage. This marker is associated with better OS and PFS in patients with leukemia. It is a novel target of ICIs. Its interspecies diversity makes this a great marker for disease progression.

The FCRL2 protein is a cell surface marker with extraordinary prognostic value. It can differentiate between M-CLL and UM-CLL. There is a strong correlation with IGHV status. Cryopreserved CLL sample cryopreserved FCRL2 provides reliable prognostic indicators of disease outcome. FCRL2 also predicts when first therapy will be administered. It can also be used to identify subsets or memory B cells.

LYN5

Boster Bio anti Fc R-like Protein 2 (FCRL2) antibodies are great for scientists who need it to analyze the FCRL2 mark in a specific species. These antibodies can recognize the human protein FCRL2. They can also be used to identify other proteins involved in signaling. The FCRL2 antibody is available in ELISA, WB, and other formats.

To activate the PTPN11 or PTPN6 genes, the FCRL2 marker must be present. It activates BCR signals through LYN. BONITA showed that downstream signaling is dependent on the CD79A, CD79B components of BCR. This study also revealed that FCRL molecule are required for activation via LYN of BCR signaling.

LYN6

There are many uses for the FCRL2 mark. It can be used for predicting the outcome of patients with MCL, especially those with deletion 13.q. It is easily testable and has a high correlation for the IGHV Gene, which can help predict when a patient will respond to therapy. It is an excellent biomarker for CLL.

It can be used to determine the frequency of immune cells within cancer cells. Studies have shown that the FCRL2 protein expression is associated with a better prognosis. The FCRL2 marker may be purchased in lentivirus or AAV formats. FCRL2 siRNA is intended for research use and not for diagnostic or therapeutic purposes. FCRL2 has been identified by researchers in many types of cancer.

LYN7

Boster Bio is proud that the FCRL2 Marker is a popular molecule. We can provide high-affinity primary antibody for your research. The antibody has been validated on immunohistochemistry, Western Blotting, and ELISA. This antibody is used worldwide by scientists in a variety of fields. Its use in research is encouraged by scientists and is not limited to animal studies.

Certain types of B cell malignancies are known to overexpress the FCRL2 protein. This means that it may be possible to target these cancerous cells with an immunotherapy strategy. FCRL2 has also been implicated in autoimmune diseases. The theory that FCRL2 regulates B-cell signaling will be supported by further research. Further studies will determine whether this marker will be useful in treating autoimmune diseases or in the treatment of B-cell malignancies.

LYN8

The FCRL2 marker, a soluble protein, is found in many tissues and cells. It is frequently used in immune-related activities. The FCRL2 protein belongs to the fc receptors family. In this article, we'll discuss its uses in immunohistochemistry. Boster Bio offers primary antibodies and blocking proteins to test for FCRL2 as well other proteins.

The BCR signaling pathway illustrates the differential regulation of FCRL genes. Rectangular, multiple-edged nodes indicate upstream regulatory of downstream genes. Smaller circular ones represent joint regulation. The color and width for rectangles can vary from red to blue. The FCRL2 genes regulate downstream signaling in the BCR. These results suggest that FCRL molecules regulate BCR signals through LYN.

LYN9

The FCRL2Marker is an anti-BCR antibody that has a profound inhibitory effect on BCR signalling. This marker recruits Src homology region two domain phosphatase-1, a protein that binds to the FCRL2 molecule. Boster Bio has validated its antibodies in Western Blotting, Immunohistochemistry, and ELISA. Boster Bio developed the FCRL2 antigen, but it is now freely available for researchers worldwide.

The presence of FCRL2 in certain B-cell malignancies suggests that there may be an immunotherapy to target this protein. Numerous clinical trials have confirmed this finding. FCRL2 will be further investigated to confirm its effectiveness as an immunotherapy target. It will be a valuable research tool in the meantime. The Best Uses of The FCRL2 marker

LYN10

You can choose from different flow procedures for Lyn10. This will ensure that your experiments are optimized. You should always follow the instructions as many flow protocols have multiple steps. Boster Bio's optimization guide will help you choose the right one. The optimization guide includes helpful tips and tricks. After you've completed your experiments, you can publish them in journals or on the internet.