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Ficolin-1 Antibodies
AND FCN1 ELISA kits, Ficolin-1 Proteins
Many biological assays use antibodies to detect Ficolin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ficolin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ficolin-1 antibodies...
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FCN1 Infographic by Boster Bio
All FCN1 Products
Product
Figures
Specificity
Applications
Price
Human Ficolin-1 / FCN1 / M Ficolin ELISA Kit PicoKine®
1 Citations 8 Q&As
Human
ELISA
$750
Cat # EK1257
96 wells/kit, with removable strips.
Cat # EK1257
96 wells/kit, with removable strips.
Human
ELISA
$499
Cat # FEK1257
96 wells/kit, with removable strips.
Cat # FEK1257
96 wells/kit, with removable strips.
FCN1 Overview
Facts about Ficolin-1.
Ficolin-1 (FCN1)
Extracellular lectin functioning as a pattern- recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system.
May also activate monocytes via a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6- linked sialic acid derivatives and to various glycans containing sialic acid participated in a 2-3 linkage.
Gene Information
| Human | |
|---|---|
| Gene Name: | FCN1 |
| Uniprot: | O00602 |
| Entrez: | 2219 |
Family
| Belongs to: |
|---|
| ficolin lectin family |
Alternative Names
Collagen/fibrinogen domain-containing protein 1; FCN1; Fcna; FCNM; FCNMficolin-A; ficolin (collagen/fibrinogen domain containing) 1; ficolin (collagen/fibrinogen domain-containing) 1; Ficolin1; Ficolin-1; Ficolin-A; ficolin-alpha; M-ficolin
Molecular Weight
Mass (kDA):
35.078 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q34.3 |
| Sequence: | 9; NC_000009.12 (134903232..134917912, complement) |
Tissue Specificity
Peripheral blood leukocytes, monocytes and granulocytes. Also detected in spleen, lung, and thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes.
Subcellular Localizations
Secreted. Cell membrane; Peripheral membrane protein; Extracellular side. Found on the monocyte and granulocyte surface (PubMed:20400674).
Diseases
- Arthritis
- Inflammation
- Rheumatoid Arthritis
- Cholangiocarcinoma
- Autoimmunity
- Cystic Fibrosis
- Malaise
- Reperfusion Injury
- Chronic Fatigue Syndrome
- Chronic Inflammation
- Inflammatory Bowel Diseases
- Thyroiditis
- Autoimmune Diseases
Interacting Proteins
- PTX3
Pathways
- Complement Activation
- Coagulation
- Acute-phase Response
- Localization
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FCN1
bosterbio.com/bosterbio-gene-info-cards/FCN1
References
PMID: 8573080 by Lu J., et al. Human ficolin: cDNA cloning, demonstration of peripheral blood leucocytes as the major site of synthesis and assignment of the gene to chromosome 9.
PMID: 8947836 by Harumiya S., et al. Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1.
1 Publications of Boster Ficolin-1 Antibodies & ELISA Kits
- PubMed ID: 34212320, Moulana Z,Bagherzadeh M,Mirzakhani M,Rostami A,Mohammadnia-Afrouzi M,Shahbazi M....
*More publications can be found for each product on its corresponding product page