FCMR Antibodies

AND FCMR ELISA kits, FCMR Proteins

Many biological assays use antibodies to detect FCMR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FCMR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FCMR antibodies...

We validate the specificity of these antibodies to FCMR by testing them on tissues known to express FCMR positively and negatively. Browse below to find the FCMR antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FCMR Infographic by Boster Bio

All FCMR Products

Product

Figures

Specificity

Applications

Price

Anti-FAIM3 (FCMR) Mouse Monoclonal Antibody [Clone ID: OTI1E6]

Human

IHC

$523
Cat # M09423
100 µl

FAIM3 (FCMR) (NM_005449) Human Over-expression Lysate

Human

$628
Cat # LS009214
100 µg

FCMR Overview

Facts about Fas apoptotic inhibitory molecule 3.

FCMR 3D structure. Source: alphafold

Fas apoptotic inhibitory molecule 3 (FCMR)

May play a role in the immune system procedures. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL.

Seems to activate an inhibitory pathway that prevents CASP8 activation after FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.

Gene Information

Human
Gene Name:	FCMR
Uniprot:	O60667
Entrez:	9214

Family

Belongs to:

No superfamily

Alternative Names

FAIM3; Fas apoptotic inhibitory molecule 3; Fc mu R; Fc mu receptor; FCMR; immunoglobulin mu Fc receptor; Regulator of Fas-induced apoptosis Toso; Toso; TOSOIgM Fc receptor

Molecular Weight

Mass (kDA):
43.146 kDA

Genomic Context


Human

Location:	1q32.1
Sequence:	1; NC_000001.11 (206903282..206922001, complement)

Tissue Specificity

Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells.

Subcellular Localizations

[Isoform 1]: Membrane; Single-pass membrane protein.; [Isoform 3]: Secreted. Detected in the serum.

Diseases

Leukemia
Lymphoid Leukemia
Chronic Lymphocytic Leukemia
Infective Disorder
Impacted Tooth
Fetal Diseases
Extravasation
Down Syndrome
Tissue Adhesions
Autoimmune Diseases
Arthritis

Malignant Neoplasms
Autoimmune Reaction
Malaria
Cytogenetic Abnormality
Cattle Diseases
Arthritis, Juvenile Rheumatoid

Pathways

Cell Adhesion
Transport
Cell Activation
Complement Activation
B Cell Activation
Transepithelial Transport
Methylation
Chemotaxis
Cell Death

Pathogenesis
Rna Interference
Lymphocyte Activation
Secretion

PTMs

Methylation

Research Areas

Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FCMR

References

PMID: 9586636 by Hitoshi Y., et al. Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells.

PMID: 21908424 by Li F.J., et al. Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (Fc?R) in patients with chronic lymphocytic leukemia.