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FBP1 Antibodies
AND FBP1 ELISA kits, FBP1 Proteins
Many biological assays use antibodies to detect FBP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FBP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FBP1 antibodies...
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FBP1 Infographic by Boster Bio
All FBP1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, ICC, WB
$405
Cat # A01377
100ul
Cat # A01377
100ul
FBP1 Overview
Facts about Fructose-1,6-bisphosphatase 1.
Fructose-1,6-bisphosphatase 1 (FBP1)
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells.
Appears to modulate glycerol gluconeogenesis in liver. Significant regulator of appetite and adiposity; increased expression of the protein in liver after nutrient surplus raises circulating satiety hormones and reduces appetite-stimulating neuropeptides and so seems to provide a feedback mechanism to limit weight gain.
Gene Information
| Human | |
|---|---|
| Gene Name: | FBP1 |
| Uniprot: | P09467 |
| Entrez: | 2203 |
Family
| Belongs to: |
|---|
| FBPase class 1 family |
Alternative Names
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; EC 3.1.3; EC 3.1.3.11; FBP; FBP1; FBPase 1; fructose-1,6-bisphosphatase 1; fructose-bisphosphatase 1; growth-inhibiting protein 17
Molecular Weight
Mass (kDA):
36.842 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q22.32 |
| Sequence: | 9; NC_000009.12 (94603133..94640263, complement) |
Tissue Specificity
Expressed in pancreatic islets.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Hypoglycemia
- Liver Carcinoma
- Malignant Neoplasm Of Breast
- Acidosis
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Fructose-1,6-diphosphatase Deficiency
- Liver Neoplasms
- Leukemia
Interacting Proteins
- BIN1
- EPAS1
- FBP2
- HIF1A
Pathways
- Gluconeogenesis
- Glycolysis
- Glyoxylate Cycle
- Chromatin Remodeling
- Translation
- Cell Growth
- Mating
- Cell Proliferation
- Virulence
- Cell Cycle
- Localization
- Pathogenesis
- Regulation Of Gene Expression
PTMs
- Phosphorylation
- Methylation
- Demethylation
- Glycosylation
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FBP1
bosterbio.com/bosterbio-gene-info-cards/FBP1
References
PMID: 2842796 by Solomon D.H., et al. Activation of the fructose 1,6-bisphosphatase gene by 1,25- dihydroxyvitamin D3 during monocytic differentiation.
PMID: 8387495 by El-Maghrabi M.R., et al. Isolation of a human liver fructose-1,6-bisphosphatase cDNA and expression of the protein in Escherichia coli. Role of Asp-118 and Asp-121 in catalysis.