Fibrillin-2 Antibodies

AND FBN2 ELISA kits, Fibrillin-2 Proteins

Many biological assays use antibodies to detect Fibrillin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Fibrillin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Fibrillin-2 antibodies...

We validate the specificity of these antibodies to Fibrillin-2 by testing them on tissues known to express FBN2 positively and negatively. Browse below to find the FBN2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FBN2 Infographic by Boster Bio

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Anti-fibrillin 2/FBN2 Antibody Picoband®

Human

ELISA, WB

$370
Cat # A03408-2
100 µg/vial

FBN2 Overview

Facts about Fibrillin-2.

Fibrillin-2 (FBN2)

Fibrillin-2: Fibrillins are structural components of 10- 12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly.

Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. .

Gene Information

Human
Gene Name:	FBN2
Uniprot:	P35556
Entrez:	2201

Family

Belongs to:

fibrillin family

Alternative Names

CCA; congenital contractural arachnodactyly; DA9; fibrillin 2; fibrillin 5; fibrillin-2

Molecular Weight

Mass (kDA):
314.775 kDA

Genomic Context


Human

Location:	5q23.3
Sequence:	5; NC_000005.10 (128257909..128538245, complement)

Tissue Specificity

Expressed in fetal eye (18 weeks)in the retinal pigment epithelium (RPE), the choroid, Bruch's membrane and in the sclera. Not expressed in the neural retina.

Subcellular Localizations

Secreted, extracellular space, extracellular matrix.

Diseases

Marfan Syndrome
Arachnodactyly
Marfanoid Joint Hypermobility Syndrome
Congenital Contractural Arachnodactyly
Connective Tissue Diseases
Muscle Contracture
Malignant Neoplasms
Aneurysm
Scoliosis, Unspecified
Hypoplasia
Neoplasms
Flexed Fetal Attitude

Kyphoscoliosis Deformity Of Spine
Syndactyly
Pathological Dilatation
Colorectal Cancer
Carcinoma
Intracranial Aneurysm
Acquired Kyphosis

Interacting Proteins

FBN1
FN1

Pathways

Methylation
Dna Methylation
Pathogenesis
Osteoblast Differentiation
Localization
Gene Silencing
Tissue Remodeling
Dna Hypermethylation
Regulation Of Signaling
Fibroblast Proliferation
Lung Development
Muscle Atrophy

Reverse Transcription
Cell Death
Bone Remodeling
Organ Formation
Bone Resorption
Tissue Homeostasis
Bone Mineralization

PTMs

Methylation

Demethylation

Reduction

Research Areas

Cell Biology
Cellular Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FBN2

References

PMID: 8120105 by Zhang H., et al. Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.

PMID: 1852206 by Lee B., et al. Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.