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- Table of Contents
Facts about Protocadherin Fat 2.
.
Human | |
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Gene Name: | FAT2 |
Uniprot: | Q9NYQ8 |
Entrez: | 2196 |
Belongs to: |
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No superfamily |
protocadherin Fat 2; CDHF8; CDHR9; FAT tumor suppressor homolog 2 (Drosophila); HFAT2; MEGF1
Mass (kDA):
479.317 kDA
Human | |
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Location: | 5q33.1 |
Sequence: | 5; NC_000005.10 (151504092..151594822, complement) |
Expressed in epidermal keratinocytes, infant brain, cerebellum, and also in a variety of tumors, such as pancreatic cancer, diffuse type gastric cancer, ovarian cancer, esophageal cancer, skin squamous cell carcinoma, head and neck cancer. Not expressed in melanoma cell line A375 cells, normal epidermal melanocytes or normal dermal fibroblasts. Expressed in epidermal keratinocytes and squamous cell carcinoma (at protein level).
Cell membrane; Single-pass type I membrane protein. Cell junction. Golgi apparatus, trans-Golgi network. Localized at adhesion zippers (early state of adherens junctions) of keratinocytes.
PMID: 10716726 by Wu Q., et al. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.
PMID: 9693030 by Nakayama M., et al. Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening.