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- Table of Contents
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FAS Antibodies
AND FAS ELISA kits, FAS Proteins
Many biological assays use antibodies to detect FAS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FAS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FAS antibodies...
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FAS Infographic by Boster Bio
All FAS Products
Product
Figures
Specificity
Applications
Price
Human FAS/Cd95 ELISA Kit PicoKine®
1 Citations 7 Q&As
Human
ELISA
$499
Cat # EK0335
96 wells/kit, with removable strips.
Cat # EK0335
96 wells/kit, with removable strips.
Mouse FAS/Cd95 ELISA Kit PicoKine®
6 Citations 8 Q&As
Mouse
ELISA
$499
Cat # EK0336
96 wells/kit, with removable strips.
Cat # EK0336
96 wells/kit, with removable strips.
Anti-Fas/Cd95 Rabbit Monoclonal Antibody
2 Citations 4 Q&As
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00055
100 μl
Cat # M00055
100 μl
Anti-Fas Antibody Picoband®
4 Citations
Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00055
100 μg/vial
Cat # A00055
100 μg/vial
FAS Overview
Facts about Tumor necrosis factor receptor superfamily member 6.
Tumor necrosis factor receptor superfamily member 6 (FAS)
Receptor for TNFSF6/FASLG.
The adapter molecule FADD recruits caspase-8 to the activated receptor.The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of older T-cells, or both.
Gene Information
| Human | |
|---|---|
| Gene Name: | FAS |
| Uniprot: | P25445 |
| Entrez: | 355 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ALPS1A; APO-1 cell surface antigen; Apo-1; apoptosis antigen 1; apoptosis signaling receptor FAS; Apoptosis-mediating surface antigen FAS; APT1; CD95 antigen; CD95; Fas (TNF receptor superfamily, member 6); Fas AMA; FAS1; FASLG receptor; FASTM; mutant tumor necrosis receptor superfamily member 6; TNF receptor superfamily member 6; TNFRSF6; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6
Molecular Weight
Mass (kDA):
37.732 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q23.31 |
| Sequence: | 10; NC_000010.11 (88968429..89017059) |
Tissue Specificity
Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Secreted.; [Isoform 6]: Secreted.
Diseases
- Malignant Neoplasms
- Neoplasms
- Fetal Alcohol Syndrome
- Carcinoma
- Obesity
- Autoimmune Reaction
- Malignant Neoplasm Of Breast
- Inflammation
- Mammary Neoplasms
- Fatty Liver
- Autoimmune Diseases
- Diabetes Mellitus
Interacting Proteins
- CASP8
- CAV1
- DAXX
- FADD
- FASLG
- MAP3K5
- Pdcd6
- PML
- PTPN13
- SRC
Pathways
- Cell Death
- Pathogenesis
- Cell Proliferation
- Secretion
- Cell Cycle
- Cell Growth
- Induction Of Apoptosis
- Immune Response
- Programmed Cell Death
- Localization
- Transport
- Fatty Acid Oxidation
- Virulence
PTMs
- Phosphorylation
- Cleavage
- Oxidation
- Methylation
- Reduction
- Acetylation
- Ribosylation
- Demethylation
- Decarboxylation
- Dephosphorylation
Research Areas
- Apoptosis
- Cancer
- Diabetes Research
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FAS
bosterbio.com/bosterbio-gene-info-cards/FAS
References
PMID: 1713127 by Itoh N., et al. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis.
PMID: 1375228 by Oehm A., et al. Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.
30 Publications of Boster FAS Antibodies & ELISA Kits
- PubMed ID: PMID:26617948, Significance of Fas and FasL protein expression in cardiac carcinoma and local l...
- PubMed ID: 10.3748/wjg.v16.i10.1274, Clinical significance of Fas and FasL protein expression in gastric carcinoma an...
- PubMed ID: 10.3390/ijms20040920, Potential Analysis and Preparation of Chitosan Oligosaccharides as Oral Nutritio...
- PubMed ID: 10.1039/C6FO00071A, The effect of geniste on Aβ25–35-induced PC12 cell apoptosis through the JNK-...
- PubMed ID: 10.1016/j.cbi.2016.08.013, Role of Cyt-C/caspases-9,3, Bax/Bcl-2 and the FAS death receptor pathway in apop...
- PubMed ID: 10.1007/s11356-021-15453-6, Perfluorooctanoic acid exposure in early pregnancy induces oxidative stress in m...
- PubMed ID: 10.1002/cbf.1523, Inhibitory effect of mesenchymal stem cells on lymphocyte proliferation
- PubMed ID: -, Lanfen Chen,Wei Chen,Mengbei Zhang et al.Comparison of therapeutic effects of me...
- PubMed ID: -, Yan Zhang,Linchao Zhang,JiaLu Bao et al.Perfluorooctanoic Acid Exposure in Early...
- PubMed ID: 33513976, Ferguson Bennit HR,Gonda A,Kabagwira J,Oppegard L,Chi D,Licero Campbell J,De Leo...
- PubMed ID: 26571489, Osteoprotegerin Induces Apoptosis of Osteoclasts and Osteoclast Precursor Cells ...
- PubMed ID: 25935138, HSP70 inhibits stress-induced cardiomyocyte apoptosis by competitively binding t...
- PubMed ID: 15973771, Construction and identification of Fas-targeting siRNA-expressing plasmid
- PubMed ID: 28032492, Croton Tiglium Extract Induces Apoptosis via Bax/Bcl-2 Pathways in Human Lung Ca...
- PubMed ID: 26617948, Significance of Fas and FasL protein expression in cardiac carcinoma and local l...
- PubMed ID: 2839182, Clinical significance of Fas and FasL protein expression in gastric carcinoma an...
- PubMed ID: 28333135, Yeung CK, Wang G, Yao Y, Liang J, Tenny Chung CY, Chuai M, Lee KK, Yang X. Cell ...
- PubMed ID: 24999110, Weng T, Xie Y, Yi L, Huang J, Luo F, Du X, Chen L, Liu C, Chen D, Chen L. Osteoa...
- PubMed ID: 22173501, Li W, Xia D, Wang Y, Li Y, Xue Y, Wu X, Ye Z. J Huazhong Univ Sci Technolog Med ...
- PubMed ID: 23422113, Liu Wl, Liu Zw, Li Ts, Wang C, Zhao B. Chin Med J (Engl). 2013 Feb;126(3):494-9....
- PubMed ID: 23671449, Ma H, Zhang X, Zhang X, Yang D, Meng L, Zhang Y, Zhou S. Arch Med Sci. 2013 Apr ...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page