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- Table of Contents
Facts about Protein lifeguard 2.
May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. .
Human | |
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Gene Name: | FAIM2 |
Uniprot: | Q9BWQ8 |
Entrez: | 23017 |
Belongs to: |
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BI1 family |
Fas apoptotic inhibitory molecule 2; KIAA0950NGP35; LFG2; LFGLIFEGUARD; NMP35neural membrane protein 35; Protein lifeguard; TMBIM2lifeguard; transmembrane BAX inhibitor motif containing 2; Transmembrane BAX inhibitor motif-containing protein 2
Mass (kDA):
35.11 kDA
Human | |
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Location: | 12q13.12 |
Sequence: | 12; NC_000012.12 (49866896..49903900, complement) |
Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus.
Cell membrane; Multi-pass membrane protein. Membrane raft. Cell junction, synapse, postsynaptic cell membrane.
PMID: 10535980 by Somia N.V., et al. LFG: an anti-apoptotic gene that provides protection from fas- mediated cell death.
PMID: 16964429 by Reimers K., et al. Sequence analysis shows that Lifeguard belongs to a new evolutionarily conserved cytoprotective family.