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- Table of Contents
Facts about Palladin.
May serve as a scaffolding molecule with the potential to affect both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins which bind to either monomeric or filamentous actin.
Human | |
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Gene Name: | PALLD |
Uniprot: | Q8WX93 |
Entrez: | 23022 |
Belongs to: |
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myotilin/palladin family |
CGI151; CGI-151; FLJ22190; FLJ38193; KIAA0992FLJ39139; MYN; myoneurin; Palladin; palladin, cytoskeletal associated protein; PALLD; PNCA1; Sarcoma antigen NY-SAR-77; SIH002; SIH002FLJ61376
Mass (kDA):
150.564 kDA
Human | |
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Location: | 4q32.3 |
Sequence: | 4; NC_000004.12 (168497039..168928441) |
Detected in both muscle and non-muscle tissues. High expression in prostate, ovary, colon, and kidney. Not detected in spleen, skeletal muscle, lung and peripheral blood lymphocytes (at protein level). Protein is overexpressed in FA6, HPAF, IMIM-PC2, SUIT-2 and PancTu-II sporadic pancreatic cancer cell lines.
Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, myofibril, sarcomere, Z line. Cell projection, ruffle. Cell projection, podosome. Cell projection, lamellipodium. Cell projection, axon. Cell projection, growth cone. Localizes to stress fibers and Z lines (PubMed:11598191, PubMed:16125169, PubMed:17322171, PubMed:17537434). Preferentially expressed in the excitatory presynaptic terminals (By similarity).
PMID: 12601173 by Lee S.-Y., et al. Immunomic analysis of human sarcoma.
PMID: 11598191 by Mykkaenen O.-M., et al. Characterization of human palladin, a microfilament-associated protein.