Erythropoietin receptor Antibodies

Erythropoietin receptor (EPOR)

Receptor for erythropoietin.

Mediates erythropoietin- induced erythroblast proliferation and differentiation.

Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3.

Gene Information

Human
Gene Name:	EPOR
Uniprot:	P19235
Entrez:	2057

Family

Belongs to:
type I cytokine receptor family

Alternative Names

EpoR; EPO-R; Erythropoietin R; erythropoietin receptor; MGC138358

Molecular Weight

Mass (kDA):
55.065 kDA

Genomic Context

Human
Location:	19p13.2
Sequence:	19; NC_000019.10 (11377207..11384314, complement)

Tissue Specificity

Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early- stage erythroid progenitor cells.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.; [Isoform EPOR-S]: Secreted. Secreted and located to the cell surface.

Diseases

• Anemia
• Neoplasms
• Hypoxia
• Malignant Neoplasms
• Polycythemia
• Acute Erythroblastic Leukemia
• Tumor Angiogenesis
• Leukemia
• Ischemia
• Carcinoma
• Erythrocytosis
• Polycythemia Vera
• Cerebrovascular Accident

• Janiceps
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Malignant Paraganglionic Neoplasm
• Brain Injuries
• Familial Erythrocytosis
• Cell Transformation, Neoplastic

Interacting Proteins

• ATXN2L
• Cish
• EPO
• PLCG2
• PTPN1

• PTPN6
• SOCS2

Pathways

• Cell Proliferation
• Angiogenesis
• Neuroprotection
• Pathogenesis
• Cell Death
• Cell Growth
• Secretion
• Hypersensitivity
• Reverse Transcription
• Cell Cycle
• Transport
• Neurogenesis
• Cell Differentiation

• Cognition
• Regeneration
• Cell Adhesion
• Glycosylation
• S Phase
• Programmed Cell Death
• Brain Development

PTMs

• Phosphorylation
• Glycosylation
• Carbamylation
• Dephosphorylation

• Cleavage
• Biotinylation
• Phosphorothioation
• Reduction

• Deglycosylation

Research Areas

• Angiogenesis
• Immunology
• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EPOR

Boster Bio - Best Uses Of The EPOR Marker

If you are new in the world of antibody research, there may be some questions you have. Boster Bio provides high-affinity primary antibodies. You can use your smartphone to detect the EPOR Marker. Here are some tips for optimizing your experiments. These tips will help you design your own experiments. To learn more, visit the Boster bio optimization guide.

Boster Bio provides high-affinity primary antibodies

Boster Bio has been providing high-affinity primary antibody based on the EPOR marker for more than two decades. These antibodies can be used in a variety of therapeutic applications, including tumor immunotherapy. The EPOR-marked antibodies are safe and have minimal risk of causing adverse immune reactions. These antibodies were affinity-matured and selected in the context of human self antigens. They also come from a unique source, a prophylactic vaccine trial, and were originally identified and affinity-matured without cancer. Their unique source of antibodies from human has allowed them to be developed and used as reagents for cancer immunotherapy.

The EPOR Marker can be detected by a smartphone

Researchers have created a new device that can detect three disease markers in just fifteen minutes using a finger prick. The device replicates laboratory-based functions such as enzyme-linked immunosorbent tests, but it does not rely upon stored energy. The device instead uses the power of the smartphone to power the immunoassay. This device can detect HIV, treponemal, specific anti-syphilis, and the nontreponemal immune system for active syphilis.

Researchers at the University of California-Irvine have developed a method to detect the EPOR Marker on smartphones. They found that patients diagnosed with glioblastoma had EPOR levels significantly higher than normal tissues. This study suggests that the EPOR Marker could be useful in certain cancer types. Future developments could include smartphone-based EPOR testing.

Researchers have shown that EPOR is able to predict the prognosis and treatment for COAD. The findings show that high levels of EPOR expression are better predictive of COAD, MESO, and LUAD patients than low levels of the gene. Further studies are needed to validate these results. This biomarker could be used to diagnose various diseases once it has been validated.