This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
EPS8 Antibodies
AND EPS8 ELISA kits, EPS8 Proteins
Many biological assays use antibodies to detect EPS8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EPS8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EPS8 antibodies...
Previous: CCN2
Next: ERCC4
EPS8 Infographic by Boster Bio
All EPS8 Products
Product
Figures
Specificity
Applications
Price
EPS8 Overview
Facts about Epidermal growth factor receptor kinase substrate 8.
Epidermal growth factor receptor kinase substrate 8 (EPS8)
Signaling adapter which controls various cellular protrusions by regulating actin cytoskeleton architecture and dynamics. Depending on its association with other signal transducers, can modulate different processes.
Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac- specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling actions based on the context.
Gene Information
| Human | |
|---|---|
| Gene Name: | EPS8 |
| Uniprot: | Q12929 |
| Entrez: | 2059 |
Family
| Belongs to: |
|---|
| EPS8 family |
Alternative Names
epidermal growth factor receptor kinase substrate 8; epidermal growth factor receptor pathway substrate 8; Eps8
Molecular Weight
Mass (kDA):
91.882 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12p12.3 |
| Sequence: | 12; NC_000012.12 (15620134..15789388, complement) |
Tissue Specificity
Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells.
Subcellular Localizations
Cytoplasm, cell cortex. Cell projection, ruffle membrane. Cell projection, growth cone. Cell projection, stereocilium. Cell junction, synapse, synaptosome. Localizes at the tips of the stereocilia of the inner and outer hair cells (By similarity). Localizes to the midzone of dividing cells.
Diseases
- Neoplasms
- Malignant Neoplasms
- Tissue Adhesions
- Cell Transformation, Neoplastic
- Carcinoma
- Neoplasm Metastasis
- Malignant Paraganglionic Neoplasm
- Cell Invasion
- Metaplastic Cell Transformation
- Carcinogenesis
- Protrusion
- Adenoma
- Malignant Tumor Of Colon
Interacting Proteins
- ALDH7A1
- BAIAP2
- BAIAP2L1
- BORCS6
- BYSL
- C19orf25
- CASK
- EGFR
- GOLGA8DP
- GRB2
Pathways
- Cell Proliferation
- Cell Migration
- Localization
- Cell Motility
- Endocytosis
- Cell Growth
- Cell Adhesion
- Spermatogenesis
- Cell Cycle
- Axon Guidance
- Dna Replication
- Oncogenesis
- Cellular Localization
PTMs
- Phosphorylation
- Biotinylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EPS8
bosterbio.com/bosterbio-gene-info-cards/EPS8
References
PMID: 8084614 by Wong W.T., et al. Evolutionary conservation of the EPS8 gene and its mapping to human chromosome 12q23-q24.
PMID: 7537362 by Karlsson T., et al. Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins.