Alpha-endosulfine Antibodies

AND ENSA ELISA kits, Alpha-endosulfine Proteins

Many biological assays use antibodies to detect Alpha-endosulfine, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Alpha-endosulfine in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Alpha-endosulfine antibodies...

We validate the specificity of these antibodies to Alpha-endosulfine by testing them on tissues known to express ENSA positively and negatively. Browse below to find the ENSA antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ENSA Infographic by Boster Bio

All ENSA Products

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Specificity

Applications

Price

ENSA (NM_207168) Human Recombinant Protein

$813
Cat # PROTO43768
20 µg

ENSA (NM_207042) Human Over-expression Lysate

Human

$628
Cat # LS002029
100 µg

ENSA Overview

Facts about Alpha-endosulfine.

ENSA 3D structure. Source: alphafold

Alpha-endosulfine (ENSA)

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated in Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, resulting in inactivation of PP2A, an important condition to keep cyclin-B1-CDK1 action high during M phase (By similarity).

Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. .

Gene Information

Human
Gene Name:	ENSA
Uniprot:	O43768
Entrez:	2029

Family

Belongs to:

endosulfine family

Alternative Names

alpha-endosulfine; ARPP-19eMGC4319; endosulfine alpha; MGC78563; MGC8394

Molecular Weight

Mass (kDA):
13.389 kDA

Genomic Context


Human

Location:	1q21.3
Sequence:	1; NC_000001.11 (150621246..150629622, complement)

Tissue Specificity

Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas.

Subcellular Localizations

Cytoplasm.

Diseases

Diabetes Mellitus
Obesity
Diabetes Mellitus, Non-insulin-dependent
Hypertensive Disease
Hepatitis B
Neoplasms
Hepatitis
Liver Neoplasms
Parkinson Disease
Cardiovascular Diseases
Proteinuria Of Undiagnosed Cause
Dyslipidemias

Neoplasm Metastasis
Diabetic Nephropathy
Spinal Cord Injuries
Down Syndrome
Aneuploidy
Infertility
Carcinoma

Interacting Proteins

Pathways

Insulin Secretion
Secretion
Translation
Regulation Of Insulin Secretion
Mitosis
Dna Methylation
Metaphase
Localization
Methylation
Regeneration
Reverse Transcription

Coagulation
Prophase
Interphase
Exocytosis
Meiosis

PTMs

Phosphorylation

Methylation

Dephosphorylation

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ENSA

References

PMID: 9653196 by Heron L., et al. Human alpha-endosulfine, a possible regulator of sulfonylurea- sensitive K(ATP) channel: molecular cloning, expression and biological properties.

PMID: 10480622 by Heron L., et al. Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta- cell K(ATP) channels.