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Egl nine homolog 1 Antibodies
AND EGLN1 ELISA kits, Egl nine homolog 1 Proteins
Many biological assays use antibodies to detect Egl nine homolog 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Egl nine homolog 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Egl nine homolog 1 antibodies...
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EGLN1 Overview
Facts about Egl nine homolog 1.
Egl nine homolog 1 (EGLN1)
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a particular proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A.
Also hydroxylates HIF2A. Has a preference for the CODD website for the two HIF1A and HIF1B.
Gene Information
| Human | |
|---|---|
| Gene Name: | EGLN1 |
| Uniprot: | Q9GZT9 |
| Entrez: | 54583 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
C1orf12; C1orf12HPH2; EC 1.14.11; EC 1.14.11.-; ECYT3; egl nine homolog 1 (C. elegans); egl nine homolog 1; egl nine-like protein 1; EGLN1; HIF prolyl hydroxylase 2; HIFPH2 EGL nine (C.elegans) homolog 1; HIFPH2; HIF-PH2; HIF-prolyl hydroxylase 2; HPH2; HPH-2; Hypoxia-inducible factor prolyl hydroxylase 2; PHD2; PHD2SM20; Prolyl hydroxylase domain-containing protein 2; SM20; SM-20; zinc finger MYND domain-containing protein 6; ZMYND6; ZMYND6DKFZp761F179
Molecular Weight
Mass (kDA):
46.021 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q42.2 |
| Sequence: | 1; NC_000001.11 (231363756..231422332, complement) |
Tissue Specificity
According to PubMed:11056053, widely expressed with highest levels in skeletal muscle and heart, moderate levels in pancreas, brain (dopaminergic neurons of adult and fetal substantia nigra) and kidney, and lower levels in lung and liver. According to PubMed:12351678 widely expressed with highest levels in brain, kidney and adrenal gland. Expressed in cardiac myocytes, aortic endothelial cells and coronary artery smooth muscle. According to PubMed:12788921; expressed in adult and fetal heart, brain, liver, lung, skeletal muscle and kidney. Also expressed in placenta. Highest levels in adult heart, brain, lung and liver and fetal brain, heart spleen and skeletal muscle.
Subcellular Localizations
Cytoplasm. Nucleus. Mainly cytoplasmic. Shuttles between the nucleus and cytoplasm (PubMed:19631610). Nuclear export requires functional XPO1.
Diseases
- Hypoxia
- Neoplasms
- Von Hippel-lindau Syndrome
- Malignant Neoplasms
- Anoxia
- Tumor Angiogenesis
- Carcinoma
- Erythrocytosis
- Pathologic Neovascularization
- Cell Transformation, Neoplastic
- Anemia
- Neoplasm Metastasis
Interacting Proteins
- EPAS1
- FKBP8
- HIF1A
- OS9
Pathways
- Angiogenesis
- Response To Hypoxia
- Localization
- Rna Interference
- Oxygen Homeostasis
- Cell Proliferation
- Cell Cycle
- Glycolysis
- Cell Death
- Cellular Response To Hypoxia
- Pathogenesis
- Tube Formation
- Transport
PTMs
- Hydroxylation
- Ubiquitination
- Phosphorylation
- Methylation
Research Areas
- Cancer
- Hypoxia
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EGLN1
bosterbio.com/bosterbio-gene-info-cards/EGLN1
References
PMID: 11056053 by Dupuy D., et al. Mapping, characterization, and expression analysis of the SM-20 human homologue, C1orf12, and identification of a novel related gene, SCAND2.
PMID: 11574160 by Taylor M.S.; Characterization and comparative analysis of the EGLN gene family.