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- Table of Contents
1 Citations 15 Q&As
1 Citations 16 Q&As
Facts about Histone-lysine N-methyltransferase EZH2.
Willing to mono-, di- and trimethylate'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses action when increasingly more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599).
Human | |
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Gene Name: | EZH2 |
Uniprot: | Q15910 |
Entrez: | 2146 |
Belongs to: |
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class V-like SAM-binding methyltransferase superfamily |
EC 2.1.1; EC 2.1.1.43; enhancer of zeste (Drosophila) homolog 2; enhancer of zeste 2; enhancer of zeste homolog 2 (Drosophila); Enhancer of zeste homolog 2; ENX1; ENX-1KMT6EZH1KMT6A; EZH2; histone-lysine N-methyltransferase EZH2; KMT6; Lysine N-methyltransferase 6; MGC9169
Mass (kDA):
85.363 kDA
Human | |
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Location: | 7q36.1 |
Sequence: | 7; NC_000007.14 (148807374..148884344, complement) |
Expressed in many tissues. Overexpressed in numerous tumor types including carcinomas of the breast, colon, larynx, lymphoma and testis.
Nucleus.
PMID: 8954776 by Chen H., et al. Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2.
PMID: 9214638 by Laible G., et al. Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres.
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