Eyes absent homolog 3 Antibodies

AND EYA3 ELISA kits, Eyes absent homolog 3 Proteins

Many biological assays use antibodies to detect Eyes absent homolog 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Eyes absent homolog 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Eyes absent homolog 3 antibodies...

We validate the specificity of these antibodies to Eyes absent homolog 3 by testing them on tissues known to express EYA3 positively and negatively. Browse below to find the EYA3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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EYA3 Infographic by Boster Bio

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Anti-Eyes absent homolog 3 EYA3 Antibody

Human, Mouse, Rat

$405
Cat # A06067
100ul

EYA3 Overview

Facts about Eyes absent homolog 3.

EYA3 3D structure. Source: alphafold

Eyes absent homolog 3 (EYA3)

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress.

Promotes efficient DNA repair by dephosphorylating H2AX, boosting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its function in transcription regulation during organogenesis.

Gene Information

Human
Gene Name:	EYA3
Uniprot:	Q99504
Entrez:	2140

Family

Belongs to:

HAD-like hydrolase superfamily

Alternative Names

DKFZp686C132; EC 3.1.3.48; eyes absent (Drosophila) homolog 3; eyes absent 3; eyes absent homolog 3 (Drosophila); eyes absent homolog 3

Molecular Weight

Mass (kDA):
62.663 kDA

Genomic Context


Human

Location:	1p35.3
Sequence:	1; NC_000001.11 (27970344..28088671, complement)

Subcellular Localizations

Cytoplasm. Nucleus. Localizes at sites of DNA damage at double-strand breaks (DSBs) (PubMed:19234442). With decreasing efficiency, translocalized to the nucleus by SIX2 and SIX5, and SIX4, respectively (By similarity).

Diseases

Branchio-oto-renal Syndrome
Malignant Neoplasms
Neoplasms
Neoplasm Metastasis
Pituitary Diseases
Genotoxic Stress
Malignant Bone Neoplasm
Congenital Ocular Coloboma (disorder)
Microphthalmos
Williams Syndrome
Anophthalmos
Malignant Neoplasm Of Breast

Neoplasm Invasiveness
Sarcoma
Ewings Sarcoma-primitive Neuroectodermal Tumor (pnet)
Malignant Childhood Neoplasm
Tumor Angiogenesis
Scleral Diseases
Peripheral Nerve Sheath Neoplasm

Pathways

Eye Development
Dna Repair
Organ Development
Rna Interference
Sprouting Angiogenesis
Cell Proliferation
Cell Migration
Muscle Cell Differentiation
Aging
Tube Formation
Photoperiodism
Cell Fate Determination
Localization

Sensitization
Muscle Hypertrophy
Cell Motility
Cell Death
Cell Differentiation
Angiogenesis
Embryonic Organ Development

PTMs

Phosphorylation

Dephosphorylation

Research Areas

Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EYA3

References

PMID: 9020840 by Abdelhak S., et al. A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family.

PMID: 9049631 by Zimmerman J.E., et al. Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene.