Eyes absent homolog 2 Antibodies

AND EYA2 ELISA kits, Eyes absent homolog 2 Proteins

Many biological assays use antibodies to detect Eyes absent homolog 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Eyes absent homolog 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Eyes absent homolog 2 antibodies...

We validate the specificity of these antibodies to Eyes absent homolog 2 by testing them on tissues known to express EYA2 positively and negatively. Browse below to find the EYA2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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EYA2 Infographic by Boster Bio

All EYA2 Products

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Product

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Specificity

Applications

Price

Human EYA2 Recombinant Protein

SDS-PAGE

$265
Cat # PROTO00167
Starting from 10ug

Anti-Zebrafish Eya2 Antibody

Zebrafish

$470
Cat # DZ41115
200 μl/vial

Anti-EYA2 Rabbit Monoclonal Antibody

Human

$370
Cat # M05074
100 μl/vial

EYA2 Overview

Facts about Eyes absent homolog 2.

EYA2 3D structure. Source: alphafold

Eyes absent homolog 2 (EYA2)

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and likely also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1.

'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis.

Gene Information

Human
Gene Name:	EYA2
Uniprot:	O00167
Entrez:	2139

Family

Belongs to:

HAD-like hydrolase superfamily

Alternative Names

EAB1EC 3.1.3.48; eyes absent (Drosophila) homolog 2; eyes absent homolog 2 (Drosophila); eyes absent homolog 2; MGC10614

Molecular Weight

Mass (kDA):
59.232 kDA

Genomic Context


Human

Location:	20q13.12
Sequence:	20; NC_000020.11 (46894624..47188844)

Tissue Specificity

Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.

Subcellular Localizations

Cytoplasm. Nucleus. Retained in the cytoplasm via interaction with GNAZ and GNAI2 (PubMed:10906137). Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus (PubMed:10906137, PubMed:12500905).

Diseases

Malignant Neoplasms
Neoplasms
Neoplasm Metastasis
Carcinoma
Crest Syndrome
Branchio-oto-renal Syndrome
Malignant Neoplasm Of Breast
Adenocarcinoma
Hypertrophy
Cardiac Hypertrophy
Sarcoma
Fibrosis
Scleral Diseases

Peripheral Nerve Sheath Neoplasm
Nerve Sheath Tumors
Non-small Cell Lung Carcinoma
Malignant Paraganglionic Neoplasm
Malignant Peripheral Nerve Sheath Tumor
Inflammation
Congenital Ocular Coloboma (disorder)

Interacting Proteins

SIX1

Pathways

Eye Development
Cell Death
Neurogenesis
Somitogenesis
Localization
Limb Development
Cell Differentiation
Cell Proliferation
Methylation
Pathogenesis
Rna Interference
Cell Adhesion
Cell Activation

Programmed Cell Death
Gene Silencing
Olfactory Placode Development
Olfactory Placode Formation
Tube Formation
Cell Fate Determination
Tendon Development

PTMs

Phosphorylation

Methylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EYA2

References

PMID: 9195991 by Duncan M.K., et al. Eyes absent: a gene family found in several metazoan phyla.

PMID: 9020840 by Abdelhak S., et al. A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family.