Eyes absent homolog 1 Antibodies

AND EYA1 ELISA kits, Eyes absent homolog 1 Proteins

Many biological assays use antibodies to detect Eyes absent homolog 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Eyes absent homolog 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Eyes absent homolog 1 antibodies...

We validate the specificity of these antibodies to Eyes absent homolog 1 by testing them on tissues known to express EYA1 positively and negatively. Browse below to find the EYA1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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EYA1 Infographic by Boster Bio

All EYA1 Products

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Specificity

Applications

Price

Anti-EYA1/4 Antibody

Human, Rat

$405
Cat # A02376
100ul

Anti-EYA1/EYA4 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A02376-1
100ul

EYA1 (NM_172060) Human Over-expression Lysate

Human

$960
Cat # LS002138
100 µg

EYA1 Overview

Facts about Eyes absent homolog 1.

EYA1 3D structure. Source: alphafold

Eyes absent homolog 1 (EYA1)

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1.

'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity).

Gene Information

Human
Gene Name:	EYA1
Uniprot:	Q99502
Entrez:	2138

Family

Belongs to:

HAD-like hydrolase superfamily

Alternative Names

BOP; BOR; EC 3.1.3.48; eyes absent (Drosophila) homolog 1; eyes absent homolog 1 (Drosophila); eyes absent homolog 1; MGC141875

Molecular Weight

Mass (kDA):
64.593 kDA

Genomic Context


Human

Location:	8q13.3
Sequence:	8; NC_000008.11 (71197433..71548104, complement)

Tissue Specificity

In the embryo, highly expressed in kidney with lower levels in brain. Weakly expressed in lung. In the adult, highly expressed in heart and skeletal muscle. Weakly expressed in brain and liver. No expression in eye or kidney.

Subcellular Localizations

Cytoplasm. Nucleus. Localizes at sites of DNA damage at double-strand breaks (DSBs).

Diseases

Branchio-oto-renal Syndrome
Complete Hearing Loss
Hypoplasia
Congenital Absence
Congenital Abnormality
Kidney Failure, Chronic
Kidney Diseases
Pathologic Fistula
Haploinsufficiency
Branchioma
Crest Syndrome
Malignant Neoplasms
Neoplasms

Congenital Absence Of Kidney
Kidney Failure
Pituitary Diseases
Branchiooculofacial Syndrome
Branchial Clefts-congenital Disorder
Craniofacial Abnormalities
Eye Abnormalities

Interacting Proteins

SIX1

Pathways

Kidney Development
Ear Development
Pathogenesis
Inner Ear Development
Organ Development
Cell Death
Cell Differentiation
Eye Development
Cell Proliferation
Neurogenesis
Localization
Cell Development
Methylation

Dna Repair
Sensory Organ Development
Translation
System Development
Cell Cycle
Cell Adhesion
Neural Tube Closure

PTMs

Phosphorylation
Methylation

Acetylation
Dephosphorylation

Sumoylation

Research Areas

Protein Phosphatase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EYA1

References

PMID: 9361030 by Abdelhak S., et al. Clustering of mutations responsible for branchio-oto-renal (BOR) syndrome in the eyes absent homologous region (eyaHR) of EYA1.

PMID: 9020840 by Abdelhak S., et al. A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family.