EVC Antibodies

AND EVC ELISA kits, EVC Proteins

Many biological assays use antibodies to detect EVC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EVC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EVC antibodies...

We validate the specificity of these antibodies to EVC by testing them on tissues known to express EVC positively and negatively. Browse below to find the EVC antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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EVC Infographic by Boster Bio

All EVC Products

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Ellis van Creveld syndrome (EVC) (NM_153717) Human Recombinant Protein

$1249
Cat # PROTP57679
20 µg

Ellis van Creveld syndrome (EVC) (NM_153717) Human Over-expression Lysate

Human

$960
Cat # LS002121
100 µg

EVC Overview

Facts about Ellis-van Creveld syndrome protein.

EVC 3D structure. Source: alphafold

Ellis-van Creveld syndrome protein (EVC)

Part of the EvC complicated that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development.

Gene Information

Human
Gene Name:	EVC
Uniprot:	P57679
Entrez:	2121

Family

Belongs to:

No superfamily

Alternative Names

Ellis van Creveld syndrome; ellis-van Creveld syndrome protein

Molecular Weight

Mass (kDA):
111.99 kDA

Genomic Context


Human

Location:	4p16.2
Sequence:	4; NC_000004.12 (5711199..5829043)

Tissue Specificity

Found in the developing vertebral bodies, ribs, upper and lower limbs, heart, kidney, lung.

Subcellular Localizations

Cell membrane; Single-pass membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Cell projection, cilium membrane. EVC2 is required for the localization of EVC at the base of primary cilia. The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner.

Diseases

Ellis-van Creveld Syndrome
Dysplasia
Polydactyly
Dwarfism
Glaucoma
Tooth Abnormalities
Intraocular Pressure Disorder
Dysostoses
Cholera
Skeletal Dysplasia
Congenital Heart Defects

Curry-hall Syndrome
Heart Diseases
Ectodermal Dysplasia
Congenital Heart Disease
Endocardial Cushion Defects
Common Atrium

Pathways

Pathogenesis
Ossification
Reflex
Vasoconstriction
Vasodilation
Localization
Transport
Intraflagellar Transport
Visual Perception
Endochondral Ossification
Heart Development
Transposition
Osteoblast Differentiation

Proteolysis
Chondrocyte Hypertrophy
Chondrocyte Proliferation
Inflammatory Response
Cartilage Development
Cell Differentiation
Bone Development

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EVC

References

PMID: 10700184 by Ruiz-Perez V.L., et al. Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis.

PMID: 18947413 by Ulucan H., et al. Extending the spectrum of Ellis van Creveld syndrome: a large family with a mild mutation in the EVC gene.