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- Table of Contents
Facts about Epithelial splicing regulatory protein 1.
Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing throughout the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs.
Human | |
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Gene Name: | ESRP1 |
Uniprot: | Q6NXG1 |
Entrez: | 54845 |
Belongs to: |
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ESRP family |
epithelial splicing regulatory protein 1; FLJ20171; RBM35A; RMB35A; RNA binding motif protein 35A; RNA-binding motif protein 35A; RNA-binding protein 35A
Mass (kDA):
75.585 kDA
Human | |
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Location: | 8q22.1 |
Sequence: | 8; NC_000008.11 (94640999..94707466) |
Epithelial cell-specific.
Nucleus.
PMID: 19285943 by Warzecha C.C., et al. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing.
PMID: 29107558 by Rohacek A.M., et al. ESRP1 mutations cause hearing loss due to defects in alternative splicing that disrupt cochlear development.