Syncytin-1 Antibodies

AND ERVW-1 ELISA kits, Syncytin-1 Proteins

Many biological assays use antibodies to detect Syncytin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Syncytin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Syncytin-1 antibodies...

We validate the specificity of these antibodies to Syncytin-1 by testing them on tissues known to express ERVW-1 positively and negatively. Browse below to find the ERVW-1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ERVW-1 Infographic by Boster Bio

All ERVW-1 Products

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Anti-ERVW-1 Antibody Picoband®

7 Q&As

Human

$370
Cat # PB9622
100 μg/vial

ERVW-1 Overview

Facts about Syncytin-1.

ERVW-1 3D structure. Source: alphafold

Syncytin-1 (ERVW-1)

This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium through placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).

Gene Information

Human
Gene Name:	ERVW-1
Uniprot:	Q9UQF0
Entrez:	30816

Family

Belongs to:

gamma type-C retroviral envelope protein family

Alternative Names

endogenous retroviral family W, env(C7), member 1; ENV; envelope glycoprotein; Envelope polyprotein gPr73; enverin; ENVW; Env-W; HERV-7q Envelope protein; HERV7Q; HERV-7q; HERV-tryptophan envelope protein; HERV-W Env glycoprotein; HERV-W envelope protein; HERV-W; HERV-W_7q21.2 provirus ancestral Env polyprotein; HERV-W{7q21.1} provirus ancestral Env polyprotein; HERVWENV; HERV-W-ENV; HERVWenvelope protein; human endogenous retrovirus W envC7-1 envelope protein; syncytin A; Syncytin; syncytin-1

Molecular Weight

Mass (kDA):
59.866 kDA

Genomic Context


Human

Location:	7q21.2
Sequence:	7; NC_000007.14 (92468380..92477946, complement)

Tissue Specificity

Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia.

Subcellular Localizations

[Surface protein]: Cell membrane; Peripheral membrane protein. The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM.; [Transmembrane protein]: Cell membrane; Single-pass type I membrane protein.; [Syncytin-1]: Virion.

Diseases

Choriocarcinoma

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERVW-1

References

PMID: 9882319 by Blond J.-L., et al. Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family.

PMID: 10693809 by Sha M., et al. Syncytin is captive retroviral envelope protein involved in human placental morphogenesis.