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- Table of Contents
Facts about Adhesion G protein-coupled receptor E2.
In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signs likely through G- proteins.
Human | |
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Gene Name: | ADGRE2 |
Uniprot: | Q9UHX3 |
Entrez: | 30817 |
Belongs to: |
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G-protein coupled receptor 2 family |
CD312; DKFZp781B135; egf-like module containing, mucin-like, hormone receptor-like 2; egf-like module containing, mucin-like, hormone receptor-like sequence 2; EGF-like module receptor 2; EGF-like module-containing mucin-like hormone receptor-like 2; EMR2
Mass (kDA):
90.472 kDA
Human | |
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Location: | 19p13.12 |
Sequence: | 19; NC_000019.10 (14732392..14778560, complement) |
Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested. High expression in mast cells (PubMed:26841242).
Cell membrane; Multi-pass membrane protein. Cell projection, ruffle membrane; Multi-pass membrane protein. Localized at the leading edge of migrating cells.
PMID: 10903844 by Lin H.-H., et al. Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97.
PMID: 12860403 by Chang G.-W., et al. Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif.