ERCC6 Antibodies

AND ERCC6 ELISA kits, ERCC6 Proteins

Many biological assays use antibodies to detect ERCC6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ERCC6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ERCC6 antibodies...

We validate the specificity of these antibodies to ERCC6 by testing them on tissues known to express ERCC6 positively and negatively. Browse below to find the ERCC6 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ERCC6 Infographic by Boster Bio

All ERCC6 Products

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Product

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Specificity

Applications

Price

Anti-CSB/ERCC6 Antibody Picoband®

1 Q&As

Human

$370
Cat # PB10060
100 μg/vial

Anti-ERCC6 Antibody

Human, Mouse, Rat

$405
Cat # A01519
100ul

Anti-CSB ERCC6 Antibody

Human

ELISA, IHC

$380
Cat # A01519-1
100ul

ERCC6 Overview

Facts about Chimeric ERCC6-PGBD3 protein.

ERCC6 3D structure. Source: alphafold

Chimeric ERCC6-PGBD3 protein (ERCC6)

Involved in repair of DNA damage after UV irradiation, acting in the absence of ERCC6 or synergistically with ERCC6. Involved in the regulation of gene expression.

In the absence of ERCC6, induces the expression of genes characteristic of interferon-like antiviral responses. This response is almost completely suppressed in the presence of ERCC6.

Gene Information

Human
Gene Name:	ERCC6
Uniprot:	P0DP91
Entrez:	2074

Family

Belongs to:

No superfamily

Alternative Names

ARMD5; ATP-dependent helicase ERCC6; CKN2; Cockayne syndrome group B protein; Cockayne syndrome protein CSB; COFS; COFS1; CSBCockayne syndrome B protein; DNA excision repair protein ERCC-6; EC 3.6.1; EC 3.6.4.-; excision repair cross-complementing rodent repair deficiency, complementationgroup 6; Rad26 homolog; RAD26

Molecular Weight

Mass (kDA):
119.487 kDA

Genomic Context


Human

Location:	10q11.23
Sequence:	10; NC_000010.11 (49454470..49539538, complement)

Tissue Specificity

Expressed in heart and oocytes, but not in granulosa cells (at protein level).

Subcellular Localizations

Nucleus.

Diseases

Cockayne Syndrome
Malignant Neoplasms
Neoplasms
Hereditary Diseases
Xeroderma Pigmentosum
Premature Aging Syndrome
Xeroderma
Carcinoma
Skin Neoplasms
Cachexia
Dwarfism
Malignant Neoplasm Of Lung

Microcephaly
Carcinogenesis
Neurodegenerative Disorders
Cell Transformation, Neoplastic
Nerve Degeneration
Malignant Neoplasm Of Skin

Pathways

Dna Repair
Aging
Hypersensitivity
Chromatin Remodeling
Cell Proliferation
Cell Cycle
Cell Death
Pathogenesis
Mismatch Repair
Methylation
Nucleotide-excision Repair
Localization
Dna Excision

Rna Interference
Response To Oxidative Stress
Dna Methylation
Dna Replication
Atp-dependent Chromatin Remodeling
Metaphase
Regulation Of Dna Repair

PTMs

Phosphorylation
Methylation
Ubiquitination

Dephosphorylation
Phosphorothioation
Acetylation

Oxidation

Research Areas

Cancer
DNA Repair
Nucleotide Excision Repair

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERCC6

References

PMID: 18369450 by Newman J.C., et al. An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome.

PMID: 22483866 by Bailey A.D., et al. The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.