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Erbin Antibodies
AND ERBIN ELISA kits, Erbin Proteins
Many biological assays use antibodies to detect Erbin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Erbin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Erbin antibodies...
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ERBIN Infographic by Boster Bio
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ERBIN Overview
Facts about Erbin.
Erbin (ERBIN)
Acts as an adapter for the receptor ERBB2, in epithelia.
By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728).Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728). .
Gene Information
| Human | |
|---|---|
| Gene Name: | ERBIN |
| Uniprot: | Q96RT1 |
| Entrez: | 55914 |
Family
| Belongs to: |
|---|
| LAP (LRR and PDZ) protein family |
Alternative Names
Erbin
Molecular Weight
Mass (kDA):
158.298 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q12.3 |
| Sequence: | 5; NC_000005.10 (65926554..66082546) |
Tissue Specificity
Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine.
Subcellular Localizations
Cell junction, hemidesmosome. Nucleus membrane. Basolateral cell membrane. Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity).
Interacting Proteins
- NOD2
- PKP4
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERBIN
bosterbio.com/bosterbio-gene-info-cards/ERBIN
References
PMID: 10878805 by Borg J.-P., et al. ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor.
PMID: 11375975 by Favre B., et al. The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression.