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1 Citations 4 Q&As
Facts about Erythropoietin receptor.
Receptor for erythropoietin.
Mediates erythropoietin- induced erythroblast proliferation and differentiation.Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3.
Human | |
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Gene Name: | EPOR |
Uniprot: | P19235 |
Entrez: | 2057 |
Belongs to: |
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type I cytokine receptor family |
EpoR; EPO-R; Erythropoietin R; erythropoietin receptor; MGC138358
Mass (kDA):
55.065 kDA
Human | |
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Location: | 19p13.2 |
Sequence: | 19; NC_000019.10 (11377207..11384314, complement) |
Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early- stage erythroid progenitor cells.
Cell membrane; Single-pass type I membrane protein.; [Isoform EPOR-S]: Secreted. Secreted and located to the cell surface.
PMID: 2163695 by Winkelmann J.C., et al. The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p.
PMID: 2163696 by Jones S.S., et al. Human erythropoietin receptor: cloning, expression, and biologic characterization.
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