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ENTPD5 Antibodies
AND ENTPD5 ELISA kits, ENTPD5 Proteins
Many biological assays use antibodies to detect ENTPD5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ENTPD5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ENTPD5 antibodies...
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ENTPD5 Overview
Facts about Ectonucleoside triphosphate diphosphohydrolase 5.
Ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5)
Uridine diphosphatase (UDPase) that boosts protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, in addition to elevated ATP consumption in the cytosol via an ATP hydrolysis cycle.
Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate.
Gene Information
| Human | |
|---|---|
| Gene Name: | ENTPD5 |
| Uniprot: | O75356 |
| Entrez: | 957 |
Family
| Belongs to: |
|---|
| GDA1/CD39 NTPase family |
Alternative Names
CD39 antigen-like 4; CD39L4; CD39L4NTPDase 5; CD39-like 4; EC 3.6.1; EC 3.6.1.42; EC 3.6.1.6; ectonucleoside triphosphate diphosphohydrolase 5; ENTPD5; ER-UDPase; GDPase ENTPD5; Guanosine-diphosphatase ENTPD5; MGC163357; MGC163359; NTPDase 5; NTPDase-5; Nucleoside diphosphatase; Pcph proto-oncogene protein; PCPH; proto-oncogene CPH; UDPase ENTPD5; Uridine-diphosphatase ENTPD5
Molecular Weight
Mass (kDA):
47.517 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q24.3 |
| Sequence: | 14; NC_000014.9 (73957916..74019326, complement) |
Tissue Specificity
Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues.
Subcellular Localizations
Endoplasmic reticulum. Secreted.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Paraganglionic Neoplasm
- Carcinoma
- Carcinogenesis
- Neoplasm Metastasis
- Intraepithelial Neoplasia
- Carcinoma In Situ
- Mammary Neoplasms
- Prostatic Intraepithelial Neoplasias
- Prostatic Neoplasms
- Malignant Neoplasm Of Prostate
Interacting Proteins
- MXI1
Pathways
- Glycolysis
- Cell Proliferation
- Translation
- Cell Growth
- Glycosylation
- Cell Maturation
- Drug Resistance
- Protein Glycosylation
- Sensitization
PTMs
- Glycosylation
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ENTPD5
bosterbio.com/bosterbio-gene-info-cards/ENTPD5
References
PMID: 9676430 by Chadwick B.P., et al. The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster.
PMID: 10708485 by Recio J.A., et al. The human PCPH proto-oncogene: cDNA identification, primary structure, chromosomal mapping, and expression in normal and tumor cells.