Ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2)

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent.

The order of activity with various substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP. .