Elastin Antibodies

Elastin (ELN)

Major structural protein of tissues such as aorta and nuchal ligament, which must expand quickly and recover completely. Molecular determinant of the late vascular morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity).

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Gene Information

Human
Gene Name:	ELN
Uniprot:	P15502
Entrez:	2006

Family

Belongs to:
elastin family

Alternative Names

elastin; FLJ38671; FLJ43523; SVAS; tropoelastin; WBS; WS

Molecular Weight

Mass (kDA):
68.398 kDA

Genomic Context

Human
Location:	7q11.23
Sequence:	7; NC_000007.14 (74027772..74069907)

Tissue Specificity

Expressed within the outer myometrial smooth muscle and throughout the arteriolar tree of uterus (at protein level). Also expressed in the large arteries, lung and skin.

Subcellular Localizations

Secreted, extracellular space, extracellular matrix. Extracellular matrix of elastic fibers.

Diseases

• Williams Syndrome
• Stenosis
• Aortic Valve Stenosis
• Supravalvular Aortic Stenosis
• Haploinsufficiency
• Leukemia
• Aneurysm
• Hypertensive Disease
• Myeloid Leukemia
• Myeloid Leukemia, Chronic
• Vascular Diseases
• Intracranial Aneurysm

• Cutis Laxa
• Neoplasms
• Developmental Disabilities
• Hypercalcemia
• Malignant Neoplasms
• Leukemia, Myelocytic, Acute
• Aortic Aneurysm

Interacting Proteins

• EFEMP2
• FBLN5
• LOX

Pathways

• Pathogenesis
• Aging
• Cognition
• Cell Proliferation
• Lung Development
• Localization
• Translation
• Cell Cycle
• Metaphase
• Regeneration
• Social Behavior
• Transport
• Cell Activation

• Muscle Cell Proliferation
• Proteolysis
• Dosage Compensation
• Reflex
• Inflammatory Response
• Mrna Stabilization
• Vasoconstriction

PTMs

• Phosphorylation

• Biotinylation

Research Areas

• Extracellular Matrix

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ELN

Boster Bio ELN Marker

ELN can be used to identify immunologically relevant markers. This marker is able to recognize human cells and can be used in monitoring the inflammatory response. It has been studied extensively for over 25 years. Its use in immunohistochemistry and Western blotting has been extensively validated. Here are the top research uses of ELN. Each of these markers are described in more detail in the article.

IL-1b

A Boster Bio ELN Marker is an ELISA kit for the quantitative determination of IL-1b and MMP-3 in human dermal fibroblast cultures. The boster bio ELN kit is a high-affinity ELISA kit with a high sensitivity that has been validated by Western Blotting, Immunohistochemistry, and ELISA.

MMP-3

ELN stands for expression of the elastinlike network. ELN is a characteristic of the human body and contributes to the formation new blood vessels as well as other tissues. A decrease in ELN expression is associated with arterial thickening in humans and a marked rise in the risk of obstructive vascular diseases. Research has many benefits for ELN.

The biopharma informatics landscape is fragmented and complex. The data landscape in biopharma informatics is complex and chaotic. There are many data sources and weak point-to-point integrations. Biopharma companies often have data that is generated from multiple sources, and scientists' work processes. TetraScience's ELN/LIMS platform utilizes a mental model for workflow to move primary information from data sources to data targets, thereby organizing the often-chaotic data landscape.