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MARK2 Antibodies
AND MARK2 ELISA kits, MARK2 Proteins
Many biological assays use antibodies to detect MARK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MARK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MARK2 antibodies...
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MARK2 Infographic by Boster Bio
All MARK2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # M02117-1
100 μl/vial
Cat # M02117-1
100 μl/vial
MARK2 Overview
Facts about Serine/threonine-protein kinase MARK2.
Serine/threonine-protein kinase MARK2 (MARK2)
Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2.
Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly.
Gene Information
| Human | |
|---|---|
| Gene Name: | MARK2 |
| Uniprot: | Q7KZI7 |
| Entrez: | 2011 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; EC 2.7.11.1; ELKL motif kinase 1; ELKL motif kinase; EMK-1; EMK1PAR-1; MAP/microtubule affinity-regulating kinase 2MGC99619; PAR1 homolog; Par1b; Ser/Thr protein kinase PAR-1B; serine/threonine protein kinase EMK; serine/threonine-protein kinase MARK2
Molecular Weight
Mass (kDA):
87.911 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.1 |
| Sequence: | 11; NC_000011.10 (63838928..63911020) |
Tissue Specificity
High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney.
Subcellular Localizations
Cell membrane; Peripheral membrane protein. Cytoplasm. Lateral cell membrane. Cytoplasm, cytoskeleton. Cell projection, dendrite. Cytoplasm. Phosphorylation at Thr-596 by PRKCZ/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relocation from the cell membrane to the cytoplasm.
Diseases
- Neoplasms
- Alzheimer's Disease
- Malignant Neoplasms
- Tissue Adhesions
- Insulin Sensitivity
- Malignant Neoplasm Of Stomach
- Carcinoma
- Diabetes Mellitus
- Tauopathies
- Carcinogenesis
- Stomach Neoplasms
- Diabetes Mellitus, Non-insulin-dependent
- Insulin Resistance
Interacting Proteins
- MAPT
- PARD6G
- YWHAB
- YWHAG
- YWHAH
- YWHAZ
Pathways
- Localization
- Secretion
- Transport
- Virulence
- Pathogenesis
- Hyperphosphorylation
- Cell Death
- Mitochondrial Transport
- Insulin Secretion
- Glucose Homeostasis
- Cell Division
- Cell Motility
- Cell Differentiation
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
Research Areas
- Phospho-Specific
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MARK2
bosterbio.com/bosterbio-gene-info-cards/MARK2
References
PMID: 9730619 by Espinosa L., et al. Human serine/threonine protein kinase EMK1: genome structure and cDNA cloning of isoforms produced by alternative splicing.
PMID: 11433294 by Sun T.-Q., et al. PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.