ELMO2 Antibodies

AND ELMO2 ELISA kits, ELMO2 Proteins

Many biological assays use antibodies to detect ELMO2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ELMO2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ELMO2 antibodies...

We validate the specificity of these antibodies to ELMO2 by testing them on tissues known to express ELMO2 positively and negatively. Browse below to find the ELMO2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ELMO2 Infographic by Boster Bio

All ELMO2 Products

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Product

Figures

Specificity

Applications

Price

Anti-ELMO2 Antibody

Human, Mouse, Rat

$405
Cat # A07552
100ul

ELMO2 (NM_133171) Human Over-expression Lysate

Human

$960
Cat # LS063916
100 µg

ELMO2 Overview

Facts about Engulfment and cell motility protein 2.

ELMO2 3D structure. Source: alphafold

Engulfment and cell motility protein 2 (ELMO2)

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK.

Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

Gene Information

Human
Gene Name:	ELMO2
Uniprot:	Q96JJ3
Entrez:	63916

Family

Belongs to:

No superfamily

Alternative Names

ced-12 homolog 2; CED12A; ELMO-2; engulfment and cell motility 2 (ced-12 homolog, C. elegans); engulfment and cell motility 2; engulfment and cell motility protein 2; FLJ11656; hCed-12A; KIAA1834CED12CED-12; PH domain protein CED12A; Protein ced-12 homolog A

Molecular Weight

Mass (kDA):
82.615 kDA

Genomic Context


Human

Location:	20q13.12
Sequence:	20; NC_000020.11 (46366045..46407051, complement)

Tissue Specificity

Widely expressed, with a higher expression in skeletal muscle, kidney and placenta.

Subcellular Localizations

Cytoplasm. Cytoplasm, cytosol. Membrane.

Diseases

Cell Invasion
Adenocarcinoma
Neuroblastoma
Neoplasm Metastasis
Diabetic Nephropathy
Malignant Neoplasm Of Breast
Kidney Failure, Chronic
Tissue Adhesions
Yersinia Pseudotuberculosis Infections
Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent

Yersinia Infections
Malignant Neoplasms
Hiv Infections
Kidney Diseases
Mammary Neoplasms
Adenocarcinoma Of Lung (disorder)

Pathways

Cell Migration
Cell Motility
Regeneration
Phagocytosis
Tissue Regeneration
Tissue Morphogenesis
Dendrite Development
Brain Development
Virulence
Localization

Keratinocyte Migration
Chemotaxis
Axon Guidance
Secretion

PTMs

Carboxylation

Research Areas

Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ELMO2

References

PMID: 11595183 by Gumienny T.L., et al. CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.

PMID: 11703939 by Zhou Z., et al. The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway.