This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
EIF5A2 Antibodies
AND EIF5A2 ELISA kits, EIF5A2 Proteins
Many biological assays use antibodies to detect EIF5A2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EIF5A2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EIF5A2 antibodies...
Previous: Septin9
Next: TMPRSS4
EIF5A2 Infographic by Boster Bio
All EIF5A2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M05688
100 µl
Cat # M05688
100 µl
EIF5A2 Overview
Facts about Eukaryotic translation initiation factor 5A-2.
Eukaryotic translation initiation factor 5A-2 (EIF5A2)
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, likely acting downstream of decapping.
Involved in actin dynamics and cell cycle progression, mRNA decay and likely in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | EIF5A2 |
| Uniprot: | Q9GZV4 |
| Entrez: | 56648 |
Family
| Belongs to: |
|---|
| eIF-5A family |
Alternative Names
EIF-5A2; eIF-5A-2; eIF5AII; Eukaryotic initiation factor 5A isoform 2; eukaryotic initiation factor 5A; eukaryotic translation initiation factor 5A2; eukaryotic translation initiation factor 5A-2
Molecular Weight
Mass (kDA):
16.793 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q26.2 |
| Sequence: | 3; NC_000003.12 (170888418..170908637, complement) |
Tissue Specificity
Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells.
Subcellular Localizations
Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
Diseases
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Carcinoma
- Cell Invasion
- Liver Carcinoma
- Colorectal Neoplasms
- Colorectal Cancer
- Adenocarcinoma
- Liver Neoplasms
- Metastatic Malignant Neoplasm To The Lymph Node
- Non-neoplastic Disorder
Interacting Proteins
- CDC23
- DHPS
- NIF3L1
- REL
- SDCBP
Pathways
- Translation
- Cell Proliferation
- Cell Migration
- Cell Motility
- Rna Interference
- Spermatogenesis
- Transport
- Senescence
- Mrna Transport
PTMs
- Deacetylation
Research Areas
- Cancer
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EIF5A2
bosterbio.com/bosterbio-gene-info-cards/EIF5A2
References
PMID: 11325856 by Guan X.-Y.Y., et al. Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer.
PMID: 11161802 by Jenkins Z.A., et al. Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression.