EGR2 Antibodies

E3 SUMO-protein ligase EGR2 (EGR2)

Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.

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Gene Information

Human
Gene Name:	EGR2
Uniprot:	P11161
Entrez:	1959

Family

Belongs to:
EGR C2H2-type zinc-finger protein family

Alternative Names

AT591; CMT1D; CMT4E; early growth response 2 (Krox-20 homolog, Drosophila); early growth response 2; early growth response protein 2; EGR-2; FLJ14547; Krox-20 homolog, Drosophila; KROX-20, Drosophila, homolog (early growth response-2); KROX20DKFZp686J1957; Zinc finger protein Krox-20

Molecular Weight

Mass (kDA):
50.302 kDA

Genomic Context

Human
Location:	10q21.3
Sequence:	10; NC_000010.11 (62811996..62819167, complement)

Subcellular Localizations

Nucleus.

Diseases

• Charcot-marie-tooth Disease
• Nervousness
• Peripheral Neuropathy
• Neoplasms
• Crest Syndrome
• Hereditary Motor And Sensory Neuropathies
• Malignant Neoplasms
• Congenital Hypomyelinating Neuropathy
• Demyelinating Diseases
• Dejerine-sottas Disease (disorder)
• Inherited Neuropathy
• Tissue Adhesions

• Demyelination
• Atrophy
• Inflammation
• Carcinoma
• Autoimmune Reaction
• Schizophrenia

Pathways

• Myelination
• Segmentation
• Cell Cycle
• Cell Proliferation
• Cell Development
• Pathogenesis
• Hindbrain Development
• Schwann Cell Development
• Cell Differentiation
• Cell Death
• Regeneration
• Cell Activation
• Localization

• Nerve Development
• Schwann Cell Proliferation
• Schwann Cell Differentiation
• Secretion
• T Cell Anergy
• Macrophage Differentiation
• Transport

PTMs

• Phosphorylation
• Methylation
• Acetylation
• Cleavage

• Ubiquitination
• Sumoylation
• Demethylation
• Reduction

• Oxidation

Research Areas

• Chromatin Research
• Neurodegeneration
• Neuroscience
• Transcription Factors and Regulators
• Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EGR2

Best Uses Of The EGR2 Marker

The Esrp2 splicing factor modulates epithelial cell-specific isoforms. In this article, we'll cover the Methods and Applications of this gene-specific marker. We'll also discuss its products and other resources. This article will give you an overall better understanding of the EGR2 marker.

Esrp2 splicing protein modulates epithelial-specific isoforms

This study shows that Esrps are required for structural integrity at the cell-cell junction. This discovery may open the door for new therapies for cancer. Scientists had previously discovered that Esrp1 was essential for many biological processes including cancer. These findings are not yet fully understood. Further research is needed in order to determine if Esrps play a role in epithelial cell junctions.

We have identified the novel epithelial splicing factors of Esrp1 & EGFR in this study. We found that pX330-Esrp2 contained both a splicing factor and an intron, whereas pX330-Puro had guide sequences targeted exons 2 and 3. After transfection, Esrp1KO Py2T cells had been selected using puromycin at 10ng/mL over 72 hours. We then isolated clonal cell lines in 96-well format and performed amplification of genomic DNA. Finally, we confirmed Esrp1KO cells possessed both a functional copy EGFP and a amplify of genomic DNA. This protein is critical in regulating gene activity.

This discovery suggests the role of the chromatin regulators as regulators of gene expression. EGR2 can be found in different isoforms and are associated to various diseases of the innate, adaptive, and adaptive immune systems. The finding has implications for research into the development of new treatments for epithelial-specific diseases. It also offers a potential treatment for cancer, which is associated with decreased expression of certain proteins.

These antibodies are highly sensitive and have been validated for use in research. Boster antibodies have been cited extensively and are trusted by the research community. Their high-affinity primary antibodies are validated for Western Blotting, Immunohistochemistry, and ELISA. Moreover, they come with a comprehensive technical support package to ensure your success.

SNHG17 regulates prostate cancer. Its expression in PC-3 cells reversed after overexpression of SNORA71B. SNORA71B's expression completely abolished the inhibition of PC-3 cell growth by sh-SNHG17#1. SNORA71B expression in excess also inhibited the apoptosis rate of PC-3 cells.

Applications

EGR2 has a consensus gene in DMR-demethylation and is a crucial component of moDC. EGR2 knockdown has a significant impact on transcription, chromatin accessibility and DNA methylation. Furthermore, gene expression is affected with downregulated genes that are enriched the actincytoskeleton. This is vital for the survival and growth of moDC. This article examines the function of the EGR2 genes in moDC biology as well as its applications.

EGR2 marker is used to differentiate human MAC25-derived MO cells. However, EGR2 has not been shown to be required for the differentiation moDC. EGR2 can also regulate gene expression by activating or suppressing specific genes. It also associates well with the NAB2 keypressor. Early research suggested that EGR2 represses neutrophil-specific genes during monocytic maturation.

Understanding the mechanisms by which tumors escape the immune system may illuminate novel therapeutic approaches for the treatment of cancer. However, there is indirect evidence that the immune system may play a role for tumor evasion. However, no direct proof has yet been found. EGR2 promotes immune controlled tumor control. It is important to understand EGR2’s role in cancer immunotherapy. This research has significant implications regarding cancer immunotherapy.

The EGR2 gene instructs you to make early growth response proteins (EGR2). This protein binds to certain regions of DNA and controls gene activation. It regulates many genes involved with peripheral nerve myelination. This protein protects nerve cells, and enhances nerve impulse transmission. EGR2 is an essential gene for peripheral nerve myelination. Mutants of EGR2 can cause the suppression of essential myelin genes.

Methods

Alveolar macrophages play an important role in maintaining lung homeostasis and protecting the lungs from respiratory pathogens. They acquire tissue-specific functions in response to local environmental signals. McCowan et al. McCowan et.al. describe EGR2 as an exclusive feature of alveolar microphages. It is essential for their core characteristics. EGR2 loss in myeloid tissues and the ability to remove bacteria from the airways can result in tissue injury and tissue destruction.

EGR2 was overexpressed, causing senescence. This also increased the pool of reverted cells. To determine if EGR2 plays a role in senescence, we used a HMEC genome expression array to identify genes that are up-regulated during senescence. Our sample was enriched for previously published EGR2 consensus-binding sequences. EGR2 binding site were found to be present on promoters for genes up-regulated by HMEC DS.

The EGR2 gene, a zinc-finger transcription factors, regulates gene expression through binding to the cis -acting elements target genes. It has been implicated in many biological processes, including hindbrain formation, peripheral nervous systems development, and inflammatory arthritis. It has been identified as a new marker for specialized Murine macrophages.

Charcot-Marie-Tooth Type 1 and peripheral neuropathies such as Charcot-Marie-Tooth Type 1 have been linked to the EGR2 gene. The disease is marked by dysregulated Schwanncell proliferation and exit. It is a transcription factor which direct binds to the p21 enhancer. The gene was shown to interact with the p21 promoter, a component of the neuronal cortex. Myelination is also affected by the EGR2 gene.

Products

EGR2, also known to be epidermal Growth Factor receptor 2, is a gene that codes for the protein EGR2. It regulates the maturation and growth of the B cells and thymocytes. Egr inhibits cell differentiation and is essential for mature B cells in the bone. The gene also controls the activity and expression of other cytokines including insulin. Molecular and functional analyses of EGR2 demonstrate that it has a critical role in the development of insulin-producing T and B cells.

This gene plays a crucial role in peripheral nerve meelination. It is also important in the maturation or T cells and hindbrain sectionation. Mutations in this genes have been associated to several demyelinating disorders, including Congenital Hypomyelinating Negopathy, Dejerine Sottas neuropathy, Charcot Marie-Tooth, and Congenital Dejerine Sottas.

The antibody 13491-1-1-AP targets EGR2 WB, IF and ELISA. It has been shown to react with human, mouse, as well as rat samples. Data from multiple labs support its use in WB. It is compatible for many applications. Its high reactivity has allowed for many applications. There are several EGR2 antibody preparations available.