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Ephrin-B3 Antibodies
AND EFNB3 ELISA kits, Ephrin-B3 Proteins
Many biological assays use antibodies to detect Ephrin-B3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ephrin-B3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ephrin-B3 antibodies...
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EFNB3 Infographic by Boster Bio
All EFNB3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1184
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1184
1 kit, containing one 96-well plate and all necessary reagents
EFNB3 Overview
Facts about Ephrin-B3.
Ephrin-B3 (EFNB3)
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases that are crucial for migration, repulsion and adhesion during adrenal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
The signaling pathway downstream of the receptor is known as forward signaling while the signaling pathway downstream of the ephrin ligand is known as reverse signaling. Binds to, and induce the collapse of, commissural axons/growth cones in vitro.
Gene Information
| Human | |
|---|---|
| Gene Name: | EFNB3 |
| Uniprot: | Q15768 |
| Entrez: | 1949 |
Family
| Belongs to: |
|---|
| ephrin family |
Alternative Names
EFL-6; Efnb3; Elk-L3; EPH-related receptor tyrosine kinase ligand 8; Ephrin B3; EphrinB3; Ephrin-B3; Epl8; EPLG8EPH-related receptor transmembrane ligand ELK-L3; LERK-8; LERK8EFL6; NLERK-2
Molecular Weight
Mass (kDA):
35.835 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.1 |
| Sequence: | 17; NC_000017.11 (7705202..7711372) |
Tissue Specificity
Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments.
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Neoplasms
- Neuroblastoma
- Malignant Neoplasms
- Neoplasm Metastasis
- Pediatric Neoplasm
- Lung Neoplasms
- Brain Neoplasms
- Moderate Mental Retardation
- Metastatic Malignant Neoplasm To The Liver
- Malignant Neoplasm Of Breast
- Malignant Neoplasm Of Brain
- Malignant Tumor Of Colon
Interacting Proteins
- EPHA4
Pathways
- Methylation
- Dna Methylation
- Regeneration
- Cell Proliferation
- Tissue Regeneration
- Gene Silencing
- Cell Death
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EFNB3
bosterbio.com/bosterbio-gene-info-cards/EFNB3
References
PMID: 9126477 by Tang X.X., et al. cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH- related protein-tyrosine kinase receptors.
PMID: 8808709 by Gale N.W., et al. Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments.