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Protein ECT2 Antibodies
AND ECT2 ELISA kits, Protein ECT2 Proteins
Many biological assays use antibodies to detect Protein ECT2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein ECT2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein ECT2 antibodies...
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ECT2 Infographic by Boster Bio
All ECT2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M01862-1
100 µl
Cat # M01862-1
100 µl
ECT2 Overview
Facts about Protein ECT2.
Protein ECT2 (ECT2)
Guanine nucleotide exchange factor (GEF) which catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42.
Part of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling needed for the myosin contractile ring formation throughout the cell cycle cytokinesis. Regulates the translocation of RHOA in the central spindle into the equatorial region.
Gene Information
| Human | |
|---|---|
| Gene Name: | ECT2 |
| Uniprot: | Q9H8V3 |
| Entrez: | 1894 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ARHGEF31; epithelial cell transforming sequence 2 oncogene; Epithelial cell-transforming sequence 2 oncogene; FLJ10461; MGC138291; protein ECT2
Molecular Weight
Mass (kDA):
103.505 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q26.31 |
| Sequence: | 3; NC_000003.12 (172750685..172829273) |
Tissue Specificity
Expressed in lung epithelial cells (at protein level). Expressed in squamous cell carcinoma, primary non-small cell lung cancer tumors and lung adenocarcinoma.
Subcellular Localizations
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Cell junction. Cell junction, tight junction. Sequestered within the nucleus during interphase. Dispersed throughout the cytoplasm upon breakdown of the nuclear envelope during mitosis. Colocalizes with the centralspindlin complex to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalized with RhoA at the midbody. Its subcellular localization to tight junction is increased by calcium. Localized predominantly in the cytoplasm of n
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Cell Invasion
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Malignant Neoplasm Of Lung
- Glioma
- Malignant Squamous Cell Neoplasm
- Lung Neoplasms
- Metastatic Malignant Neoplasm To The Lymph Node
- Malignant Neoplasm Of Breast
Interacting Proteins
- CDH1
- CTNNA1
- KIF23
- NCK1
- PLK4
- RACGAP1
Pathways
- Cytokinesis
- Localization
- Cell Division
- Mitosis
- Cell Cycle
- Anaphase
- Rna Interference
- Cleavage Furrow Formation
- Cell Proliferation
- Metaphase
- Abscission
- Cell Migration
- S Phase
PTMs
- Cleavage
- Phosphorylation
- Dephosphorylation
Research Areas
- Phospho-Specific
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ECT2
bosterbio.com/bosterbio-gene-info-cards/ECT2
References
PMID: 10579713 by Tatsumoto T., et al. Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis.
PMID: 14587037 by Saito S., et al. Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N-terminal cell cycle regulator-related domains.