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- Table of Contents
Facts about Transcription factor E2F8.
Directly represses transcription of classical E2F transcription factors such as E2F1: part of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing activity of ancient E2F proteins (E2F1, E2F2 and/or E2F3).
Human | |
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Gene Name: | E2F8 |
Uniprot: | A0AVK6 |
Entrez: | 79733 |
Belongs to: |
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E2F/DP family |
E2F family member 8; E2F transcription factor 8; E2F-8; FLJ23311; transcription factor E2F8
Mass (kDA):
94.166 kDA
Human | |
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Location: | 11p15.1 |
Sequence: | 11; NC_000011.10 (19224063..19241655, complement) |
Nucleus.
PMID: 16179649 by Christensen J., et al. Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription.
PMID: 15897886 by Logan N., et al. E2F-8: an E2F family member with a similar organization of DNA- binding domains to E2F-7.