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DNMT1 Antibodies
AND DNMT1 ELISA kits, DNMT1 Proteins
Many biological assays use antibodies to detect DNMT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNMT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNMT1 antibodies...
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DNMT1 Infographic by Boster Bio
All DNMT1 Products
Product
Figures
Specificity
Applications
Price
Anti-Dnmt1 Rabbit Monoclonal Antibody
3 Citations 15 Q&As
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00172
100 μl
Cat # M00172
100 μl
Anti-Dnmt1 Antibody Picoband®
1 Citations 16 Q&As
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # A00172-1
100 μg/vial
Cat # A00172-1
100 μg/vial
Anti-DNMT1 Monoclonal Antibody
2 Citations 16 Q&As
Human, Mouse, Zebrafish, Fish
ChIP, IP, IHC, WB
$425
Cat # M00172-1
100ug
Cat # M00172-1
100ug
DNMT1 Overview
Facts about DNA (cytosine-5)-methyltransferase 1.
DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Methylates CpG residues.
Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is vital for epigenetic inheritance.Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It's in charge of maintaining methylation patterns based in evolution.
Gene Information
| Human | |
|---|---|
| Gene Name: | DNMT1 |
| Uniprot: | P26358 |
| Entrez: | 1786 |
Family
| Belongs to: |
|---|
| class I-like SAM-binding methyltransferase superfamily |
Alternative Names
AIM; CXXC9; CXXC9CXXC finger protein 9; CXXC-type zinc finger protein 9; DNA (cytosine-5-)-methyltransferase 1; DNA (cytosine-5)-methyltransferase 1; DNA methyltransferase 1; DNA methyltransferase HsaI; DNA MTase HsaI; DNMT; DNMT1; EC 2.1.1.37; FLJ16293; m.HsaI; MCMT; MCMTMGC104992
Molecular Weight
Mass (kDA):
183.165 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.2 |
| Sequence: | 19; NC_000019.10 (10133346..10194953, complement) |
Tissue Specificity
Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Carcinogenesis
- Malignant Neoplasm Of Breast
- Malignant Paraganglionic Neoplasm
- Leukemia
- Mammary Neoplasms
- Malignant Neoplasm Of Lung
- Colorectal Cancer
- Malignant Tumor Of Colon
Interacting Proteins
- AKT1
- CTNNB1
- EED
- EZH2
- NRIP1
- PARP1
- SETD7
- SIRT1
- UHRF1
Pathways
- Methylation
- Dna Methylation
- Demethylation
- Cell Cycle
- Gene Silencing
- Dna Hypomethylation
- Dna Replication
- Cell Proliferation
- Localization
- Dna Hypermethylation
- Dna Demethylation
- Pathogenesis
- Cell Growth
PTMs
- Methylation
- Demethylation
- Acetylation
- Phosphorylation
- Reduction
- Deacetylation
- Cleavage
- Ubiquitination
- Phosphorothioation
Research Areas
- Chromatin Research
- Core ESC-Like Genes
- Epigenetics
- Stem Cell Markers
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DNMT1
bosterbio.com/bosterbio-gene-info-cards/DNMT1
References
PMID: 1594447 by Yen R.-W.C., et al. Isolation and characterization of the cDNA encoding human DNA methyltransferase.
PMID: 8940105 by Yoder J.A., et al. New 5' regions of the murine and human genes for DNA (cytosine-5)- methyltransferase.
4 Publications of Boster DNMT1 Antibodies & ELISA Kits
- PubMed ID: 10.3892/etm.2020.9227, Melatonin prevents the binding of vascular endothelial growth factor to its rece...
- PubMed ID: 32989385, Shen C,Li Y,Chen Y,Huang L,Zhang F,Wu W.Melatonin prevents the binding of vascul...
- PubMed ID: 33194583, Zhang D,An X,Li Q,Man X,Chu M,Li H,Zhang N,Dai X,Yu H,Li Z.Thioguanine Induces A...
- PubMed ID: 29389913, Shikonin Inhibites Migration and Invasion of Thyroid Cancer Cells by Downregulat...
*More publications can be found for each product on its corresponding product page