This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
Deoxyribonuclease-1 Antibodies
AND DNASE1 ELISA kits, Deoxyribonuclease-1 Proteins
Many biological assays use antibodies to detect Deoxyribonuclease-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Deoxyribonuclease-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Deoxyribonuclease-1 antibodies...
Previous: CCN2
Next: DNASE1L1
DNASE1 Infographic by Boster Bio
All DNASE1 Products
Product
Figures
Specificity
Applications
Price
Human
$260
Cat # PROTP24855
500IU, 1500IU, 10000IU
Cat # PROTP24855
500IU, 1500IU, 10000IU
DNASE1 Overview
Facts about Deoxyribonuclease-1.
Deoxyribonuclease-1 (DNASE1)
Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:2251263, PubMed:11241278, PubMed:2277032). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity).
Among other purposes, seems to be involved in cell death by apoptosis (PubMed:11241278). Binds specifically to G- actin and blocks actin polymerization (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | DNASE1 |
| Uniprot: | P24855 |
| Entrez: | 1773 |
Family
| Belongs to: |
|---|
| DNase I family |
Alternative Names
deoxyribonuclease IFLJ38093; deoxyribonuclease-1; DKFZp686H0155; DNase I; DNase I, lysosomal; DNL1FLJ44902; Dornase alfa; DRNI; EC 3.1.21.1; human urine deoxyribonuclease I
Molecular Weight
Mass (kDA):
31.434 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.3 |
| Sequence: | 16; NC_000016.10 (3611737..3665472) |
Tissue Specificity
Principally in tissues of the digestive system. Highest levels found in urine, but also relatively abundant in semen and saliva.
Subcellular Localizations
Secreted. Nucleus envelope. Secretory protein, stored in zymogen granules and found in the nuclear envelope.
Diseases
- Cystic Fibrosis
- Fibrosis
- Lung Diseases
- Lupus Erythematosus, Systemic
- Inflammation
- Atelectasis
- Infective Disorder
- Respiratory Tract Infections
- Coughing
- Autoimmune Reaction
- Airway Obstruction
- Voice Disturbance
- Lupus Nephritis
Pathways
- Transport
- Hypersensitivity
- Localization
- Cell Death
- Pathogenesis
- Anaphylaxis
- Secretion
- Cell Proliferation
- Gene Silencing
- Programmed Cell Death
- Proteolysis
- Immune Response
- Platelet Activation
PTMs
- Cleavage
Research Areas
- Apoptosis
- DNA Repair
- DNA replication, Transcription, Translation and Splicing
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DNASE1
bosterbio.com/bosterbio-gene-info-cards/DNASE1
References
PMID: 2251263 by Shak S., et al. Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum.
PMID: 7762978 by Yasuda T., et al. Structure of the human deoxyribonuclease I (DNase I) gene: identification of the nucleotide substitution that generates its classical genetic polymorphism.
3 Publications of Boster Deoxyribonuclease-1 Antibodies & ELISA Kits
- PubMed ID: 10.1530/JME-19-0067, miRNA-155 silencing reduces sciatic nerve injury in diabetic peripheral neuropat...
- PubMed ID: 10.1371/journal.pone.0155514, The Protective Effects of Salubrinal on the Cartilage and Subchondral Bone of th...
- PubMed ID: 10.1007/s11010-020-03789-5, Functional suppression of Ripk1 blocks the NF-κB signaling pathway and induces ...
*More publications can be found for each product on its corresponding product page