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DYRK1B Antibodies
AND DYRK1B ELISA kits, DYRK1B Proteins
Many biological assays use antibodies to detect DYRK1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DYRK1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DYRK1B antibodies...
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DYRK1B Infographic by Boster Bio
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DYRK1B Overview
Facts about Dual specificity tyrosine-phosphorylation-regulated kinase 1B.
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B)
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1.
Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments.
Gene Information
| Human | |
|---|---|
| Gene Name: | DYRK1B |
| Uniprot: | Q9Y463 |
| Entrez: | 9149 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
dual specificity tyrosine-phosphorylation-regulated kinase 1B; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B; EC 2.7.12; Minibrain-related kinase; Mirk protein kinase; MIRKEC 2.7.12.1
Molecular Weight
Mass (kDA):
69.198 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.2 |
| Sequence: | 19; NC_000019.10 (39825347..39834233, complement) |
Tissue Specificity
Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines.
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Adenocarcinoma
- Pancreatic Neoplasm
- Malignant Neoplasm Of Pancreas
- Malignant Tumor Of Colon
- Down Syndrome
- Rhabdomyosarcoma
- Ovarian Neoplasm
- Neoplasm Metastasis
- Sarcoma
Interacting Proteins
- DCAF7
- HNF1A
- LZTS2
- MAP2K3
- PCBD2
- RANBP9
- RB1
- RBL1
- TROAP
Pathways
- Rna Interference
- Cell Cycle
- Localization
- Cell Migration
- Cell Growth
- Brain Development
- Nuclear Export
- Translation
- S Phase
- Nodal Signaling Pathway
- Proteolysis
- Neurogenesis
- Pigmentation
PTMs
- Phosphorylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DYRK1B
bosterbio.com/bosterbio-gene-info-cards/DYRK1B
References
PMID: 9918863 by Leder S., et al. Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases.
PMID: 10910078 by Lee K., et al. Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.