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- Table of Contents
Facts about Docking protein 4.
DOK4 works in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative connection with downstream effectors of RET in neuronal differentiation.
Human | |
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Gene Name: | DOK4 |
Uniprot: | Q8TEW6 |
Entrez: | 55715 |
Belongs to: |
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DOK family |
docking protein 4; Downstream of tyrosine kinase 4; FLJ10488; Insulin receptor substrate 5; IRS5; IRS-5
Mass (kDA):
37.028 kDA
Human | |
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Location: | 16q21 |
Sequence: | 16; NC_000016.10 (57471922..57487139, complement) |
Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells.
PMID: 12595900 by Favre C., et al. DOK4 and DOK5: new Dok-related genes expressed in human T cells.
PMID: 12730241 by Cai D., et al. Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5.