DOCK1 Antibodies

AND DOCK1 ELISA kits, DOCK1 Proteins

Many biological assays use antibodies to detect DOCK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DOCK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DOCK1 antibodies...

We validate the specificity of these antibodies to DOCK1 by testing them on tissues known to express DOCK1 positively and negatively. Browse below to find the DOCK1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DOCK1 Infographic by Boster Bio

All DOCK1 Products

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Specificity

Applications

Price

Anti-DOCK 180 (K1692) Antibody

Human, Rat

IHC, WB

$405
Cat # A03440
100ul

Anti-DOCK 180 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A03440-1
100ul

Anti-DOCK180/DOCK1 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, IHC, WB

$370
Cat # A03440-2
100 μg/vial

DOCK1 Overview

Facts about Dedicator of cytokinesis protein 1.

DOCK1 3D structure. Source: alphafold

Dedicator of cytokinesis protein 1 (DOCK1)

Involved in cytoskeletal rearrangements necessary for phagocytosis of apoptotic cells and cell motility. Together with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).

Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity could be improved by ELMO1 (PubMed:8657152).

Gene Information

Human
Gene Name:	DOCK1
Uniprot:	Q14185
Entrez:	1793

Family

Belongs to:

DOCK family

Alternative Names

180 kDa protein downstream of CRK; ced5; dedicator of cytokinesis 1; dedicator of cyto-kinesis 1; DOCK1; DOCK180; DOCK180dedicator of cytokinesis protein 1; DOwnstream of CrK

Molecular Weight

Mass (kDA):
215.346 kDA

Genomic Context


Human

Location:	10q26.2
Sequence:	10; NC_000010.11 (126905428..127452517)

Tissue Specificity

Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.

Subcellular Localizations

Cytoplasm. Membrane. Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate.

Diseases

Tissue Adhesions
Neoplasms
Cell Invasion
Malignant Neoplasms
Neoplasm Invasiveness
Malignant Paraganglionic Neoplasm
Cell Transformation, Neoplastic
Neoplasm Metastasis
Malignant Neoplasm Of Brain
Glioma
Immunologic Tolerance
Carcinoma
Tumor Angiogenesis

Ovarian Neoplasm
Trematode Infections
Protrusion
Growth Arrest
Malignant Neoplasm Of Ovary
Glioblastoma
Brain Neoplasms

Interacting Proteins

ANKRD28
ELMO1
GRB2
RAC1

Pathways

Cell Migration
Phagocytosis
Cell Motility
Localization
Myoblast Fusion
Cytokinesis
Cell Adhesion
Dorsal Closure
Cell Cycle
Cell Growth
Actin Cytoskeleton Reorganization
Cell Proliferation
Regulation Of Cell Motility

Angiogenesis
Pathogenesis
Rna Interference
Transport
Hyperphosphorylation
Response To Wounding
Programmed Cell Death

PTMs

Phosphorylation
Biotinylation
Farnesylation

Cleavage
Methylation
Ribosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DOCK1

References

PMID: 8657152 by Hasegawa H., et al. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane.

PMID: 8662907 by Matsuda M., et al. Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins.