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- Table of Contents
Facts about DNA (cytosine-5)-methyltransferase 3B.
May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co- repressor by associating with CBX4 and independently of DNA methylation.
Human | |
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Gene Name: | DNMT3B |
Uniprot: | Q9UBC3 |
Entrez: | 1789 |
Belongs to: |
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class I-like SAM-binding methyltransferase superfamily |
DNA (cytosine-5-)-methyltransferase 3 beta; DNA (cytosine-5)-methyltransferase 3B; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; DNMT3B; EC 2.1.1.37; ICF; ICF1; M.HsaIIIB
Mass (kDA):
95.751 kDA
Human | |
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Location: | 20q11.21 |
Sequence: | 20; NC_000020.11 (32762385..32809356) |
Ubiquitous; highly expressed in fetal liver, heart, kidney, placenta, and at lower levels in spleen, colon, brain, liver, small intestine, lung, peripheral blood mononuclear cells, and skeletal muscle. Isoform 1 is expressed in all tissues except brain, skeletal muscle and PBMC, 3 is ubiquitous, 4 is expressed in all tissues except brain, skeletal muscle, lung and prostate and 5 is detectable only in testis and at very low level in brain and prostate.
Nucleus.
PMID: 10433969 by Xie S., et al. Cloning, expression and chromosome locations of the human DNMT3 gene family.
PMID: 10647011 by Xu G.-L., et al. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene.