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- Table of Contents
Facts about DnaJ homolog subfamily C member 11.
.
Human | |
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Gene Name: | DNAJC11 |
Uniprot: | Q9NVH1 |
Entrez: | 55735 |
Belongs to: |
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DNAJC11 family |
dJ126A5.1; DnaJ (Hsp40) homolog, subfamily C, member 11; dnaJ homolog subfamily C member 11; FLJ10737; novel DnaJ domain-containing protein
Mass (kDA):
63.278 kDA
Human | |
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Location: | 1p36.31 |
Sequence: | 1; NC_000001.11 (6634168..6701833, complement) |
Mitochondrion. Isoforms show differential submitochondrial localization. A 57 kDa form (potentially isoform 3) shows either mitochondrial matrix or innermembrane (IM) localization, possibly anchored to the IM facing the matrix. A 35 kDa form behaved either as an inner membrane space (IMS) or an IM protein exposed to the IMS.; [Isoform 1]: Mitochondrion outer membrane; Peripheral membrane protein.
PMID: 17624330 by Xie J., et al. The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil- helix domain-containing protein 3 and 6 and DnaJC11.
PMID: 25111180 by Ioakeimidis F., et al. A splicing mutation in the novel mitochondrial protein DNAJC11 causes motor neuron pathology associated with cristae disorganization, and lymphoid abnormalities in mice.