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- Table of Contents
Facts about DnaJ homolog subfamily C member 10.
Also involved in endoplasmic reticulum-associated degradation (ERAD) by decreasing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its action, not for the disulfide reductase activity, but to facilitate the launch of DNAJC10 from its substrate.
Human | |
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Gene Name: | DNAJC10 |
Uniprot: | Q8IXB1 |
Entrez: | 54431 |
Belongs to: |
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No superfamily |
DKFZp434J1813; DnaJ (Hsp40) homolog, subfamily C, member 10; dnaJ homolog subfamily C member 10; ERdj5; ER-resident protein ERdj5; J-domain-containing protein disulfide isomerase-like protein; JPDI; macrothioredoxin; MGC104194; MTHr
Mass (kDA):
91.08 kDA
Human | |
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Location: | 2q32.1 |
Sequence: | 2; NC_000002.12 (182716257..182794464) |
Endoplasmic reticulum lumen.
PMID: 12411443 by Cunnea P.M., et al. ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress.
PMID: 14587667 by Gu S.-H., et al. Cloning and identification of a novel cDNA which encodes a putative protein with a DnaJ domain and a thioredoxin active motif, human macrothioredoxin.