DNAJB12 Antibodies

AND DNAJB12 ELISA kits, DNAJB12 Proteins

Many biological assays use antibodies to detect DNAJB12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNAJB12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNAJB12 antibodies...

We validate the specificity of these antibodies to DNAJB12 by testing them on tissues known to express DNAJB12 positively and negatively. Browse below to find the DNAJB12 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DNAJB12 Infographic by Boster Bio

All DNAJB12 Products

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Product

Figures

Specificity

Applications

Price

Anti-DNAJB12 Antibody

Human, Mouse, Rat

$405
Cat # A13448
100ul

DNAJB12 (NM_017626) Human Over-expression Lysate

Human

$628
Cat # LS054788
100 µg

DNAJB12 Overview

Facts about DnaJ homolog subfamily B member 12.

DNAJB12 3D structure. Source: alphafold

DnaJ homolog subfamily B member 12 (DNAJB12)

Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and encourage unfolded proteins into endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:21150129, PubMed:21148293). Acts by discovering HSPA8/Hsc70's ATPase and polypeptide-binding actions.

Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and building them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins depends on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661).

Gene Information

Human
Gene Name:	DNAJB12
Uniprot:	Q9NXW2
Entrez:	54788

Family

Belongs to:

DnaJ family

Alternative Names

DJ10FLJ20027; DKFZp586B2023; DnaJ (Hsp40) homolog, subfamily B, member 12; dnaJ homolog subfamily B member 12; FLJ0027

Molecular Weight

Mass (kDA):
41.86 kDA

Genomic Context


Human

Location:	10q22.1
Sequence:	10; NC_000010.11 (72332835..72354919, complement)

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Localizes to the endoplasmic reticulum membrane (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661). When overexpressed, forms membranous structures in the nucleus (PubMed:24732912).

Diseases

Cystic Fibrosis
Fibrosis
Refractory Neutropenia
Systemic Inflammatory Response Syndrome
Systemic Infection
Innate Immune Response
Tissue Adhesions

Suppressor Mutation
Inflammatory Response

Pathways

Immune Response
Localization
Inflammatory Response

PTMs

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DNAJB12

References

PMID: 21150129 by Yamamoto Y.H., et al. A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR.

PMID: 21673190 by Goodwin E.C., et al. BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient simian virus 40 infection.