TET2 Antibodies

AND TET2 ELISA kits, TET2 Proteins

Many biological assays use antibodies to detect TET2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TET2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TET2 antibodies...

We validate the specificity of these antibodies to TET2 by testing them on tissues known to express TET2 positively and negatively. Browse below to find the TET2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: Septin9 Next: KCTD9

TET2 Infographic by Boster Bio

All TET2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-TET2 Antibody

Human

ELISA, IF, IHC-P, WB

$449
Cat # A00191
0.1 mg

Anti-TET2 Antibody

Human, Mouse

ELISA, WB

$449
Cat # A00191-1
0.1 mg

Anti-TET2 Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A00191-2
100ul

TET2 Overview

Facts about Methylcytosine dioxygenase TET2.

TET2 3D structure. Source: alphafold

Methylcytosine dioxygenase TET2 (TET2)

Dioxygenase that catalyzes the conversion of this modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs.

Also mediates following conversion of 5hmC into 5- formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC to 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation.

Gene Information

Human
Gene Name:	TET2
Uniprot:	Q6N021
Entrez:	54790

Family

Belongs to:

TET family

Alternative Names

FLJ20032; MGC125715; tet methylcytosine dioxygenase 2

Molecular Weight

Mass (kDA):
223.811 kDA

Genomic Context


Human

Location:	4q24
Sequence:	4; NC_000004.12 (105145875..105279803)

Tissue Specificity

Broadly expressed. Highly expressed in hematopoietic cells; highest expression observed in granulocytes. Expression is reduced in granulocytes from peripheral blood of patients affected by myelodysplastic syndromes.

Diseases

Leukemia
Neoplasms
Leukemia, Myelocytic, Acute
Myeloid Leukemia
Dysmyelopoietic Syndromes
Myeloproliferative Disease
Malignant Neoplasms
Leukemia, Myelomonocytic, Chronic
Primary Myelofibrosis
Thrombocytosis
Myelomonocytic Leukemia
Polycythemia Vera

Thrombocythemia, Essential
Polycythemia
Cytogenetic Abnormality
Hematologic Neoplasms
Myelodysplastic-myeloproliferative Diseases
Cell Transformation, Neoplastic
Anemia

Interacting Proteins

Pathways

Pathogenesis
Methylation
Dna Methylation
Demethylation
Dna Demethylation
Dna Modification
Metaphase
Regulation Of Gene Expression
Dna Hypermethylation
Aging
Histone Modification
Cell Cycle
Interphase

Oncogenesis
Localization
Drug Resistance
Angiogenesis
Cell Activation
Cell Cycle Checkpoint
Gene Silencing

PTMs

Methylation
Demethylation
Hydroxylation

Oxidation
Phosphorylation
Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TET2

References

PMID: 12880961 by Ohira M., et al. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma.

PMID: 12646957 by Lorsbach R.B., et al. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).